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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity.
Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, Katibah GE, Kanne DB, Leong JJ, Metchette K, Bruml JR, Ndubaku CO, McKenna JM, Feng Y, Zheng L, Bender SL, Cho CY, Leong ML, van Elsas A, Dubensky TW Jr, McWhirter SM. Sivick KE, et al. Among authors: mcwhirter sm. Cell Rep. 2018 Dec 11;25(11):3074-3085.e5. doi: 10.1016/j.celrep.2018.11.047. Cell Rep. 2018. PMID: 30540940 Free article.
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.
Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky TW Jr, Kim Y. Fu J, et al. Among authors: mcwhirter sm. Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306. Sci Transl Med. 2015. PMID: 25877890 Free PMC article.
The host STING pathway at the interface of cancer and immunity.
Corrales L, McWhirter SM, Dubensky TW Jr, Gajewski TF. Corrales L, et al. Among authors: mcwhirter sm. J Clin Invest. 2016 Jul 1;126(7):2404-11. doi: 10.1172/JCI86892. Epub 2016 Jul 1. J Clin Invest. 2016. PMID: 27367184 Free PMC article. Review.
Comment on "The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele".
Sivick KE, Surh NH, Desbien AL, Grewal EP, Katibah GE, McWhirter SM, Dubensky TW Jr. Sivick KE, et al. Among authors: mcwhirter sm. J Immunol. 2017 Jun 1;198(11):4183-4185. doi: 10.4049/jimmunol.1700294. J Immunol. 2017. PMID: 28533276 No abstract available.
TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors.
Francica BJ, Ghasemzadeh A, Desbien AL, Theodros D, Sivick KE, Reiner GL, Hix Glickman L, Marciscano AE, Sharabi AB, Leong ML, McWhirter SM, Dubensky TW Jr, Pardoll DM, Drake CG. Francica BJ, et al. Among authors: mcwhirter sm. Cancer Immunol Res. 2018 Apr;6(4):422-433. doi: 10.1158/2326-6066.CIR-17-0263. Epub 2018 Feb 22. Cancer Immunol Res. 2018. PMID: 29472271 Free PMC article.
STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.
Van Dis E, Sogi KM, Rae CS, Sivick KE, Surh NH, Leong ML, Kanne DB, Metchette K, Leong JJ, Bruml JR, Chen V, Heydari K, Cadieux N, Evans T, McWhirter SM, Dubensky TW Jr, Portnoy DA, Stanley SA. Van Dis E, et al. Among authors: mcwhirter sm. Cell Rep. 2018 May 1;23(5):1435-1447. doi: 10.1016/j.celrep.2018.04.003. Cell Rep. 2018. PMID: 29719256 Free PMC article.
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer.
Kinkead HL, Hopkins A, Lutz E, Wu AA, Yarchoan M, Cruz K, Woolman S, Vithayathil T, Glickman LH, Ndubaku CO, McWhirter SM, Dubensky TW Jr, Armstrong TD, Jaffee EM, Zaidi N. Kinkead HL, et al. Among authors: mcwhirter sm. JCI Insight. 2018 Oct 18;3(20):e122857. doi: 10.1172/jci.insight.122857. JCI Insight. 2018. PMID: 30333318 Free PMC article.
SLC19A1 transports immunoreactive cyclic dinucleotides.
Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. Luteijn RD, et al. Among authors: mcwhirter sm. Nature. 2019 Sep;573(7774):434-438. doi: 10.1038/s41586-019-1553-0. Epub 2019 Sep 11. Nature. 2019. PMID: 31511694 Free PMC article.
40 results