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Page 1
Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.
Finn PD, Rodriguez D, Kohler J, Jiang Z, Wan S, Blanco E, King AJ, Chen T, Bell N, Dragoli D, Jacobs JW, Jain R, Leadbetter M, Siegel M, Carreras CW, Koo-McCoy S, Shaw K, Le C, Vanegas S, Hsu IH, Kozuka K, Okamoto K, Caldwell JS, Lewis JG. Finn PD, et al. Among authors: caldwell js. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G412-G424. doi: 10.1152/ajpgi.00300.2018. Epub 2019 Jan 3. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 30605011 Free PMC article.
Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.
Davidson JP, King AJ, Kumaraswamy P, Caldwell JS, Korner P, Blanks RC, Jacobs JW. Davidson JP, et al. Among authors: caldwell js. J Cardiovasc Pharmacol Ther. 2018 May;23(3):244-253. doi: 10.1177/1074248417741685. Epub 2017 Nov 12. J Cardiovasc Pharmacol Ther. 2018. PMID: 29130735 Free PMC article.
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.
Kozuka K, He Y, Koo-McCoy S, Kumaraswamy P, Nie B, Shaw K, Chan P, Leadbetter M, He L, Lewis JG, Zhong Z, Charmot D, Balaa M, King AJ, Caldwell JS, Siegel M. Kozuka K, et al. Among authors: caldwell js. Stem Cell Reports. 2017 Dec 12;9(6):1976-1990. doi: 10.1016/j.stemcr.2017.10.013. Epub 2017 Nov 16. Stem Cell Reports. 2017. PMID: 29153987 Free PMC article.
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS. King AJ, et al. Among authors: caldwell js. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. doi: 10.1126/scitranslmed.aam6474. Sci Transl Med. 2018. PMID: 30158152 Free PMC article. Clinical Trial.
NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
King AJ, Chang L, Li Q, Liu L, Zhu Y, Pasricha PJ, Wang J, Siegel M, Caldwell JS, Edelstein S, Rosenbaum DP, Kozuka K. King AJ, et al. Among authors: caldwell js. Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G543-G554. doi: 10.1152/ajpgi.00233.2023. Epub 2024 Jan 22. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 38252683 Free article.
Maximizing Utility of Deceased Donor Kidney Offers.
Caldwell JS, Cheng XS. Caldwell JS, et al. Clin J Am Soc Nephrol. 2023 Dec 1;18(12):1521-1523. doi: 10.2215/CJN.0000000000000349. Epub 2023 Nov 6. Clin J Am Soc Nephrol. 2023. PMID: 38064304 No abstract available.
Parsimonious discovery of synergistic drug combinations.
Severyn B, Liehr RA, Wolicki A, Nguyen KH, Hudak EM, Ferrer M, Caldwell JS, Hermes JD, Li J, Tudor M. Severyn B, et al. Among authors: caldwell js. ACS Chem Biol. 2011 Dec 16;6(12):1391-8. doi: 10.1021/cb2003225. Epub 2011 Oct 19. ACS Chem Biol. 2011. PMID: 21974780
46 results