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Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.
Palmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP. Palmer DC, et al. Among authors: guittard gc. J Exp Med. 2015 Nov 16;212(12):2095-113. doi: 10.1084/jem.20150304. Epub 2015 Nov 2. J Exp Med. 2015. PMID: 26527801 Free PMC article.
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L. Rodriguez-Peña AB, et al. Among authors: guittard gc. Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18. Gene Ther. 2015. PMID: 26018935 Free PMC article.
Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice.
Guittard G, Gallardo DL, Li W, Melis N, Lui JC, Kortum RL, Shakarishvili NG, Huh S, Baron J, Weigert R, Kramer JA, Samelson LE, Sommers CL. Guittard G, et al. Front Immunol. 2017 Mar 23;8:343. doi: 10.3389/fimmu.2017.00343. eCollection 2017. Front Immunol. 2017. PMID: 28386265 Free PMC article.
Dok-4 is a novel negative regulator of T cell activation.
Gérard A, Ghiotto M, Fos C, Guittard G, Compagno D, Galy A, Lemay S, Olive D, Nunès JA. Gérard A, et al. J Immunol. 2009 Jun 15;182(12):7681-9. doi: 10.4049/jimmunol.0802203. J Immunol. 2009. PMID: 19494292 Free PMC article.
23 results