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Vaccine protection against SIVmac239 acquisition.
Martins MA, Bischof GF, Shin YC, Lauer WA, Gonzalez-Nieto L, Watkins DI, Rakasz EG, Lifson JD, Desrosiers RC. Martins MA, et al. Among authors: lauer wa. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1739-1744. doi: 10.1073/pnas.1814584116. Epub 2019 Jan 14. Proc Natl Acad Sci U S A. 2019. PMID: 30642966 Free PMC article.
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products.
Shin YC, Bischof GF, Lauer WA, Gonzalez-Nieto L, Rakasz EG, Hendricks GM, Watkins DI, Martins MA, Desrosiers RC. Shin YC, et al. Among authors: lauer wa. PLoS Pathog. 2018 Jun 18;14(6):e1007143. doi: 10.1371/journal.ppat.1007143. eCollection 2018 Jun. PLoS Pathog. 2018. PMID: 29912986 Free PMC article.
ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge.
Alpert MD, Harvey JD, Lauer WA, Reeves RK, Piatak M Jr, Carville A, Mansfield KG, Lifson JD, Li W, Desrosiers RC, Johnson RP, Evans DT. Alpert MD, et al. Among authors: lauer wa. PLoS Pathog. 2012;8(8):e1002890. doi: 10.1371/journal.ppat.1002890. Epub 2012 Aug 23. PLoS Pathog. 2012. PMID: 22927823 Free PMC article.
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