Mettetal JT - Search Results

1

A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro.

Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS. Ramm S, et al. Among authors: mettetal jt. Toxicol Sci. 2019 May 1;169(1):54-69. doi: 10.1093/toxsci/kfz021. Toxicol Sci. 2019. PMID: 30649541 Free PMC article.

2

Systems Pharmacology Model of Gastrointestinal Damage Predicts Species Differences and Optimizes Clinical Dosing Schedules.

Shankaran H, Cronin A, Barnes J, Sharma P, Tolsma J, Jasper P, Mettetal JT. Shankaran H, et al. Among authors: mettetal jt. CPT Pharmacometrics Syst Pharmacol. 2018 Jan;7(1):26-33. doi: 10.1002/psp4.12255. Epub 2017 Dec 6. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 28941225 Free PMC article.

3

Multiscale Mathematical Model of Drug-Induced Proximal Tubule Injury: Linking Urinary Biomarkers to Epithelial Cell Injury and Renal Dysfunction.

Gebremichael Y, Lu J, Shankaran H, Helmlinger G, Mettetal J, Hallow KM. Gebremichael Y, et al. Toxicol Sci. 2018 Mar 1;162(1):200-211. doi: 10.1093/toxsci/kfx239. Toxicol Sci. 2018. PMID: 29126144

4

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.

Battista C, Yang K, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Battista C, et al. Among authors: mettetal jt. Toxicol Sci. 2018 Nov 1;166(1):123-130. doi: 10.1093/toxsci/kfy191. Toxicol Sci. 2018. PMID: 30060248 Free PMC article. Clinical Trial.

5

Systems pharmacology to predict drug safety in drug development.

Trame MN, Biliouris K, Lesko LJ, Mettetal JT. Trame MN, et al. Among authors: mettetal jt. Eur J Pharm Sci. 2016 Oct 30;94:93-95. doi: 10.1016/j.ejps.2016.05.027. Epub 2016 May 29. Eur J Pharm Sci. 2016. PMID: 27251780 Review.

6

Model-Informed Reverse and Forward Translation of Safety Risks in Drug Development.

Mettetal JT. Mettetal JT. Clin Pharmacol Ther. 2018 Feb;103(2):199-201. doi: 10.1002/cpt.925. Epub 2017 Dec 1. Clin Pharmacol Ther. 2018. PMID: 29194584

7

Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.

Svensson F, Zoufir A, Mahmoud S, Afzal AM, Smit I, Giblin KA, Clements PJ, Mettetal JT, Pointon A, Harvey JS, Greene N, Williams RV, Bender A. Svensson F, et al. Among authors: mettetal jt. Chem Res Toxicol. 2018 Nov 19;31(11):1119-1127. doi: 10.1021/acs.chemrestox.8b00159. Epub 2018 Oct 17. Chem Res Toxicol. 2018. PMID: 30350600

8

Quantifying Drug-Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model.

Fornari C, Oplustil O'Connor L, Pin C, Smith A, Yates JWT, Cheung SYA, Jodrell DI, Mettetal JT, Collins TA. Fornari C, et al. Among authors: mettetal jt. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):858-868. doi: 10.1002/psp4.12459. Epub 2019 Oct 20. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31508894 Free PMC article.

9

Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.

Yang K, Battista C, Woodhead JL, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Yang K, et al. Among authors: mettetal jt. Clin Pharmacol Ther. 2017 Apr;101(4):501-509. doi: 10.1002/cpt.619. Epub 2017 Feb 17. Clin Pharmacol Ther. 2017. PMID: 28074467 Free PMC article.

10

Understanding Hematological Toxicities Using Mathematical Modeling.

Fornari C, O'Connor LO, Yates JWT, Cheung SYA, Jodrell DI, Mettetal JT, Collins TA. Fornari C, et al. Among authors: mettetal jt. Clin Pharmacol Ther. 2018 Oct;104(4):644-654. doi: 10.1002/cpt.1080. Epub 2018 May 1. Clin Pharmacol Ther. 2018. PMID: 29604045 Review.

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