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Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.
Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE Jr, Battinelli EM. Johnson KE, et al. Among authors: kulenthirarajan r. Blood Adv. 2019 Jan 22;3(2):198-211. doi: 10.1182/bloodadvances.2018026161. Blood Adv. 2019. PMID: 30670536 Free PMC article.
CCL5 derived from platelets increases megakaryocyte proplatelet formation.
Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE Jr, Battinelli EM. Machlus KR, et al. Among authors: kulenthirarajan r. Blood. 2016 Feb 18;127(7):921-6. doi: 10.1182/blood-2015-05-644583. Epub 2015 Dec 8. Blood. 2016. PMID: 26647394 Free PMC article.
Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis.
Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE Jr, Battinelli EM. Johnson KE, et al. Among authors: kulenthirarajan r. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):664-674. doi: 10.1161/ATVBAHA.116.308791. Epub 2017 Feb 2. Arterioscler Thromb Vasc Biol. 2017. PMID: 28153880 Free PMC article.