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A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.
Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, Kwek A, Liu B, Flemming C, Chudakova DA, Pandher R, Failes TW, Lim J, Angeli A, Osterman AL, Imamura T, Kees UR, Supuran CT, Pearson RB, Hannan RD, Davis TP, McCarroll J, Kavallaris M, Turner N, Gudkov AV, Haber M, Norris MD, Henderson MJ. Somers K, et al. Among authors: kees ur. Oncogene. 2019 May;38(20):3824-3842. doi: 10.1038/s41388-018-0666-5. Epub 2019 Jan 22. Oncogene. 2019. PMID: 30670779 Free PMC article.
CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.
Somers K, Chudakova DA, Middlemiss SM, Wen VW, Clifton M, Kwek A, Liu B, Mayoh C, Bongers A, Karsa M, Pan S, Cruikshank S, Scandlyn M, Hoang W, Imamura T, Kees UR, Gudkov AV, Chernova OB, Haber M, Norris MD, Henderson MJ. Somers K, et al. Among authors: kees ur. Oncotarget. 2016 Jul 19;7(29):46067-46087. doi: 10.18632/oncotarget.10022. Oncotarget. 2016. PMID: 27317766 Free PMC article.
Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia.
Somers K, Kosciolek A, Bongers A, El-Ayoubi A, Karsa M, Mayoh C, Wadham C, Middlemiss S, Neznanov N, Kees UR, Lock RB, Gudkov A, Sutton R, Gurova K, Haber M, Norris MD, Henderson MJ. Somers K, et al. Among authors: kees ur. Int J Cancer. 2020 Apr 1;146(7):1902-1916. doi: 10.1002/ijc.32582. Epub 2019 Aug 8. Int J Cancer. 2020. PMID: 31325323 Free article.
Mechanism of relapse in pediatric acute lymphoblastic leukemia.
Henderson MJ, Choi S, Beesley AH, Sutton R, Venn NC, Marshall GM, Kees UR, Haber M, Norris MD. Henderson MJ, et al. Among authors: kees ur. Cell Cycle. 2008 May 15;7(10):1315-20. doi: 10.4161/cc.7.10.5885. Epub 2008 Feb 29. Cell Cycle. 2008. PMID: 18418081
Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia.
Somers K, Evans K, Cheung L, Karsa M, Pritchard T, Kosciolek A, Bongers A, El-Ayoubi A, Forgham H, Middlemiss S, Mayoh C, Jones L, Gupta M, Kees UR, Chernova O, Korotchkina L, Gudkov AV, Erickson SW, Teicher B, Smith MA, Norris MD, Haber M, Lock RB, Henderson MJ. Somers K, et al. Among authors: kees ur. Leukemia. 2020 Jun;34(6):1524-1539. doi: 10.1038/s41375-019-0683-6. Epub 2019 Dec 17. Leukemia. 2020. PMID: 31848452 Free PMC article.
Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin.
Karsa M, Kosciolek A, Bongers A, Mariana A, Failes T, Gifford AJ, Kees UR, Cheung LC, Kotecha RS, Arndt GM, Haber M, Norris MD, Sutton R, Lock RB, Henderson MJ, Somers K. Karsa M, et al. Among authors: kees ur. Br J Cancer. 2021 Jul;125(1):55-64. doi: 10.1038/s41416-021-01332-x. Epub 2021 Apr 9. Br J Cancer. 2021. PMID: 33837299 Free PMC article.
Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin.
Cruickshank MN, Ford J, Cheung LC, Heng J, Singh S, Wells J, Failes TW, Arndt GM, Smithers N, Prinjha RK, Anderson D, Carter KW, Gout AM, Lassmann T, O'Reilly J, Cole CH, Kotecha RS, Kees UR. Cruickshank MN, et al. Among authors: kees ur. Leukemia. 2017 Jan;31(1):40-50. doi: 10.1038/leu.2016.165. Epub 2016 Jun 13. Leukemia. 2017. PMID: 27443263 Free PMC article.
Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.
Richmond J, Carol H, Evans K, High L, Mendomo A, Robbins A, Meyer C, Venn NC, Marschalek R, Henderson M, Sutton R, Kurmasheva RT, Kees UR, Houghton PJ, Smith MA, Lock RB. Richmond J, et al. Among authors: kees ur. Clin Cancer Res. 2015 Mar 15;21(6):1395-405. doi: 10.1158/1078-0432.CCR-14-2300. Epub 2015 Jan 8. Clin Cancer Res. 2015. PMID: 25573381 Free PMC article.
160 results