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Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.
Scheinfeldt LB, Soi S, Lambert C, Ko WY, Coulibaly A, Ranciaro A, Thompson S, Hirbo J, Beggs W, Ibrahim M, Nyambo T, Omar S, Woldemeskel D, Belay G, Froment A, Kim J, Tishkoff SA. Scheinfeldt LB, et al. Among authors: beggs w. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4166-4175. doi: 10.1073/pnas.1817678116. Epub 2019 Feb 19. Proc Natl Acad Sci U S A. 2019. PMID: 30782801 Free PMC article. Clinical Trial.
Genetic adaptation to high altitude in the Ethiopian highlands.
Scheinfeldt LB, Soi S, Thompson S, Ranciaro A, Woldemeskel D, Beggs W, Lambert C, Jarvis JP, Abate D, Belay G, Tishkoff SA. Scheinfeldt LB, et al. Among authors: beggs w. Genome Biol. 2012 Jan 20;13(1):R1. doi: 10.1186/gb-2012-13-1-r1. Genome Biol. 2012. PMID: 22264333 Free PMC article.
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
Wang X, Mitra N, Secundino I, Banda K, Cruz P, Padler-Karavani V, Verhagen A, Reid C, Lari M, Rizzi E, Balsamo C, Corti G, De Bellis G, Longo L; NISC Comparative Sequencing Program; Beggs W, Caramelli D, Tishkoff SA, Hayakawa T, Green ED, Mullikin JC, Nizet V, Bui J, Varki A. Wang X, et al. Among authors: beggs w. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9935-40. doi: 10.1073/pnas.1119459109. Epub 2012 Jun 4. Proc Natl Acad Sci U S A. 2012. PMID: 22665810 Free PMC article.
Structural diversity and African origin of the 17q21.31 inversion polymorphism.
Steinberg KM, Antonacci F, Sudmant PH, Kidd JM, Campbell CD, Vives L, Malig M, Scheinfeldt L, Beggs W, Ibrahim M, Lema G, Nyambo TB, Omar SA, Bodo JM, Froment A, Donnelly MP, Kidd KK, Tishkoff SA, Eichler EE. Steinberg KM, et al. Among authors: beggs w. Nat Genet. 2012 Jul 1;44(8):872-80. doi: 10.1038/ng.2335. Nat Genet. 2012. PMID: 22751100 Free PMC article.
Shorter telomere length in Europeans than in Africans due to polygenetic adaptation.
Hansen ME, Hunt SC, Stone RC, Horvath K, Herbig U, Ranciaro A, Hirbo J, Beggs W, Reiner AP, Wilson JG, Kimura M, De Vivo I, Chen MM, Kark JD, Levy D, Nyambo T, Tishkoff SA, Aviv A. Hansen ME, et al. Among authors: beggs w. Hum Mol Genet. 2016 Jun 1;25(11):2324-2330. doi: 10.1093/hmg/ddw070. Epub 2016 Mar 2. Hum Mol Genet. 2016. PMID: 26936823 Free PMC article.
Loci associated with skin pigmentation identified in African populations.
Crawford NG, Kelly DE, Hansen MEB, Beltrame MH, Fan S, Bowman SL, Jewett E, Ranciaro A, Thompson S, Lo Y, Pfeifer SP, Jensen JD, Campbell MC, Beggs W, Hormozdiari F, Mpoloka SW, Mokone GG, Nyambo T, Meskel DW, Belay G, Haut J; NISC Comparative Sequencing Program; Rothschild H, Zon L, Zhou Y, Kovacs MA, Xu M, Zhang T, Bishop K, Sinclair J, Rivas C, Elliot E, Choi J, Li SA, Hicks B, Burgess S, Abnet C, Watkins-Chow DE, Oceana E, Song YS, Eskin E, Brown KM, Marks MS, Loftus SK, Pavan WJ, Yeager M, Chanock S, Tishkoff SA. Crawford NG, et al. Among authors: beggs w. Science. 2017 Nov 17;358(6365):eaan8433. doi: 10.1126/science.aan8433. Epub 2017 Oct 12. Science. 2017. PMID: 29025994 Free PMC article.
Correction to: African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.
Fan S, Kelly DE, Beltrame MH, Hansen MEB, Mallick S, Ranciaro A, Hirbo J, Thompson S, Beggs W, Nyambo T, Omar SA, Meskel DW, Belay G, Froment A, Patterson N, Reich D, Tishkoff SA. Fan S, et al. Among authors: beggs w. Genome Biol. 2019 Oct 9;20(1):204. doi: 10.1186/s13059-019-1821-1. Genome Biol. 2019. PMID: 31597575 Free PMC article.
112 results