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An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation.
Cole BK, Simmers MB, Feaver R, Qualls CW Jr, Collado MS, Berzin E, Figler RA, Pryor AW Jr, Lawson M, Mackey A, Manka D, Wamhoff BR, Turk JR, Blackman BR. Cole BK, et al. Among authors: figler ra. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2185-95. doi: 10.1161/ATVBAHA.115.306245. Epub 2015 Aug 20. Arterioscler Thromb Vasc Biol. 2015. PMID: 26293464
Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.
Terelius Y, Figler RA, Marukian S, Collado MS, Lawson MJ, Mackey AJ, Manka D, Qualls CW Jr, Blackman BR, Wamhoff BR, Dash A. Terelius Y, et al. Among authors: figler ra. Chem Biol Interact. 2016 Aug 5;255:31-44. doi: 10.1016/j.cbi.2015.11.023. Epub 2015 Dec 2. Chem Biol Interact. 2016. PMID: 26626330 Free PMC article.
Drug-induced steatohepatitis.
Dash A, Figler RA, Sanyal AJ, Wamhoff BR. Dash A, et al. Among authors: figler ra. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):193-204. doi: 10.1080/17425255.2017.1246534. Epub 2016 Oct 27. Expert Opin Drug Metab Toxicol. 2017. PMID: 27759439 Free PMC article. Review.
Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.
Collado MS, Cole BK, Figler RA, Lawson M, Manka D, Simmers MB, Hoang S, Serrano F, Blackman BR, Sinha S, Wamhoff BR. Collado MS, et al. Among authors: figler ra. Stem Cells Transl Med. 2017 Aug;6(8):1673-1683. doi: 10.1002/sctm.17-0004. Epub 2017 Jun 19. Stem Cells Transl Med. 2017. PMID: 28628273 Free PMC article.
Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis.
Shepherd EL, Saborano R, Northall E, Matsuda K, Ogino H, Yashiro H, Pickens J, Feaver RE, Cole BK, Hoang SA, Lawson MJ, Olson M, Figler RA, Reardon JE, Nishigaki N, Wamhoff BR, Günther UL, Hirschfield G, Erion DM, Lalor PF. Shepherd EL, et al. Among authors: figler ra. JHEP Rep. 2020 Nov 20;3(2):100217. doi: 10.1016/j.jhepr.2020.100217. eCollection 2021 Apr. JHEP Rep. 2020. PMID: 33490936 Free PMC article.
41 results