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Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes.
Haschka D, Petzer V, Kocher F, Tschurtschenthaler C, Schaefer B, Seifert M, Sopper S, Sonnweber T, Feistritzer C, Arvedson TL, Zoller H, Stauder R, Theurl I, Weiss G, Tymoszuk P. Haschka D, et al. Among authors: arvedson tl. JCI Insight. 2019 Apr 18;4(8):e98867. doi: 10.1172/jci.insight.98867. eCollection 2019 Apr 18. JCI Insight. 2019. PMID: 30996139 Free PMC article.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. Theurl I, et al. Among authors: arvedson tl. Nat Med. 2016 Aug;22(8):945-51. doi: 10.1038/nm.4146. Epub 2016 Jul 18. Nat Med. 2016. PMID: 27428900 Free PMC article.
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.
Bessman NJ, Mathieu JRR, Renassia C, Zhou L, Fung TC, Fernandez KC, Austin C, Moeller JB, Zumerle S, Louis S, Vaulont S, Ajami NJ, Sokol H, Putzel GG, Arvedson T, Sockolow RE, Lakhal-Littleton S, Cloonan SM, Arora M, Peyssonnaux C, Sonnenberg GF. Bessman NJ, et al. Science. 2020 Apr 10;368(6487):186-189. doi: 10.1126/science.aau6481. Science. 2020. PMID: 32273468 Free PMC article.
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. Billesbølle CB, et al. Nature. 2020 Oct;586(7831):807-811. doi: 10.1038/s41586-020-2668-z. Epub 2020 Aug 19. Nature. 2020. PMID: 32814342 Free PMC article.
IL-22 regulates iron availability in vivo through the induction of hepcidin.
Smith CL, Arvedson TL, Cooke KS, Dickmann LJ, Forte C, Li H, Merriam KL, Perry VK, Tran L, Rottman JB, Maxwell JR. Smith CL, et al. Among authors: arvedson tl. J Immunol. 2013 Aug 15;191(4):1845-55. doi: 10.4049/jimmunol.1202716. Epub 2013 Jul 8. J Immunol. 2013. PMID: 23836059
24 results