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Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.
Ortmann CA, Dorsheimer L, Abou-El-Ardat K, Hoffrichter J, Assmus B, Bonig H, Scholz A, Pfeifer H, Martin H, Schmid T, Brüne B, Scheich S, Steffen B, Riemann J, Hermann S, Dukat A, Bug G, Brandts CH, Wagner S, Serve H, Rieger MA. Ortmann CA, et al. Cell Rep. 2019 May 14;27(7):2022-2028.e3. doi: 10.1016/j.celrep.2019.04.064. Cell Rep. 2019. PMID: 31091442 Free article. Clinical Trial.
Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.
Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Abou-El-Ardat K, Kiefer KC, Hoffmann J, Seeger F, Bonig H, Dimmeler S, Zeiher AM, Rieger MA. Dorsheimer L, et al. Among authors: abou el ardat k. Haematologica. 2020 Jul;105(7):e328-e332. doi: 10.3324/haematol.2019.224402. Epub 2019 Nov 7. Haematologica. 2020. PMID: 31699791 Free PMC article. No abstract available.
Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.
Assmus B, Cremer S, Kirschbaum K, Culmann D, Kiefer K, Dorsheimer L, Rasper T, Abou-El-Ardat K, Herrmann E, Berkowitsch A, Hoffmann J, Seeger F, Mas-Peiro S, Rieger MA, Dimmeler S, Zeiher AM. Assmus B, et al. Among authors: abou el ardat k. Eur Heart J. 2021 Jan 20;42(3):257-265. doi: 10.1093/eurheartj/ehaa845. Eur Heart J. 2021. PMID: 33241418
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
Kiefer KC, Cremer S, Pardali E, Assmus B, Abou-El-Ardat K, Kirschbaum K, Dorsheimer L, Rasper T, Berkowitsch A, Serve H, Dimmeler S, Zeiher AM, Rieger MA. Kiefer KC, et al. Among authors: abou el ardat k. ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28. ESC Heart Fail. 2021. PMID: 33779075 Free PMC article.
Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated With Increased Mortality in Patients With Chronic Heart Failure.
Cremer S, Kirschbaum K, Berkowitsch A, John D, Kiefer K, Dorsheimer L, Wagner J, Rasper T, Abou-El-Ardat K, Assmus B, Serve H, Rieger M, Dimmeler S, Zeiher AM. Cremer S, et al. Among authors: abou el ardat k. Circ Genom Precis Med. 2020 Aug;13(4):e003003. doi: 10.1161/CIRCGEN.120.003003. Epub 2020 Jun 29. Circ Genom Precis Med. 2020. PMID: 32598856 No abstract available.
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T. Barth J, et al. Leukemia. 2019 Jun;33(6):1411-1426. doi: 10.1038/s41375-018-0375-7. Epub 2019 Jan 24. Leukemia. 2019. PMID: 30679800
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.
Malkomes P, Lunger I, Oppermann E, Abou-El-Ardat K, Oellerich T, Günther S, Canbulat C, Bothur S, Schnütgen F, Yu W, Wingert S, Haetscher N, Catapano C, Dietz MS, Heilemann M, Kvasnicka HM, Holzer K, Serve H, Bechstein WO, Rieger MA. Malkomes P, et al. Among authors: abou el ardat k. Oncogene. 2021 Jun;40(25):4352-4367. doi: 10.1038/s41388-021-01847-w. Epub 2021 Jun 8. Oncogene. 2021. PMID: 34103685 Free PMC article.
Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T. Barth J, et al. Leukemia. 2019 Jun;33(6):1541. doi: 10.1038/s41375-019-0415-y. Leukemia. 2019. PMID: 30837671
27 results