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Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells.
Dias J, Hengst J, Parrot T, Leeansyah E, Lunemann S, Malone DFG, Hardtke S, Strauss O, Zimmer CL, Berglin L, Schirdewahn T, Ciesek S, Marquardt N, von Hahn T, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H, Sandberg JK, Björkström NK. Dias J, et al. Among authors: schirdewahn t. J Hepatol. 2019 Aug;71(2):301-312. doi: 10.1016/j.jhep.2019.04.009. Epub 2019 May 14. J Hepatol. 2019. PMID: 31100314 Free PMC article.
The Third Signal Cytokine Interleukin 12 Rather Than Immune Checkpoint Inhibitors Contributes to the Functional Restoration of Hepatitis D Virus-Specific T Cells.
Schirdewahn T, Grabowski J, Owusu Sekyere S, Bremer B, Wranke A, Lunemann S, Schlaphoff V, Kirschner J, Hardtke S, Manns MP, Cornberg M, Wedemeyer H, Suneetha PV. Schirdewahn T, et al. J Infect Dis. 2017 Jan 1;215(1):139-149. doi: 10.1093/infdis/jiw514. Epub 2016 Oct 31. J Infect Dis. 2017. PMID: 27803174