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Page 1
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.
Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, Gomez H, Huang DT, Kellum JA, Mi Q, Opal SM, Talisa V, van der Poll T, Visweswaran S, Vodovotz Y, Weiss JC, Yealy DM, Yende S, Angus DC. Seymour CW, et al. Among authors: opal sm. JAMA. 2019 May 28;321(20):2003-2017. doi: 10.1001/jama.2019.5791. JAMA. 2019. PMID: 31104070 Free PMC article.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. Singer M, et al. Among authors: opal sm. JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. JAMA. 2016. PMID: 26903338 Free PMC article.
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.
Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP, Wittebole X, Dugernier T, Perrotin D, Tidswell M, Jauregui L, Krell K, Pachl J, Takahashi T, Peckelsen C, Cordasco E, Chang CS, Oeyen S, Aikawa N, Maruyama T, Schein R, Kalil AC, Van Nuffelen M, Lynn M, Rossignol DP, Gogate J, Roberts MB, Wheeler JL, Vincent JL; ACCESS Study Group. Opal SM, et al. JAMA. 2013 Mar 20;309(11):1154-62. doi: 10.1001/jama.2013.2194. JAMA. 2013. PMID: 23512062 Clinical Trial.
Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.
Laterre PF, Berry SM, Blemings A, Carlsen JE, François B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windeløv NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brulé N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjølbye AL, Angus DC; SEPSIS-ACT Investigators. Laterre PF, et al. Among authors: opal sm. JAMA. 2019 Oct 15;322(15):1476-1485. doi: 10.1001/jama.2019.14607. JAMA. 2019. PMID: 31577035 Free PMC article.
Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial.
Lewis RJ, Angus DC, Laterre PF, Kjølbye AL, van der Meulen E, Blemings A, Graves T, Russell JA, Carlsen JE, Jacobsen K, Yealy DM, Opal SM, Windeløv NA, François B, Perner A, Pickkers P, Berry SM. Lewis RJ, et al. Among authors: opal sm. Ann Am Thorac Soc. 2018 Feb;15(2):250-257. doi: 10.1513/AnnalsATS.201708-669SD. Ann Am Thorac Soc. 2018. PMID: 29388815 Clinical Trial.
Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection.
Huang DT, Yealy DM, Filbin MR, Brown AM, Chang CH, Doi Y, Donnino MW, Fine J, Fine MJ, Fischer MA, Holst JM, Hou PC, Kellum JA, Khan F, Kurz MC, Lotfipour S, LoVecchio F, Peck-Palmer OM, Pike F, Prunty H, Sherwin RL, Southerland L, Terndrup T, Weissfeld LA, Yabes J, Angus DC; ProACT Investigators. Huang DT, et al. N Engl J Med. 2018 Jul 19;379(3):236-249. doi: 10.1056/NEJMoa1802670. Epub 2018 May 20. N Engl J Med. 2018. PMID: 29781385 Free PMC article. Clinical Trial.
Host-pathogen interactions in sepsis.
van der Poll T, Opal SM. van der Poll T, et al. Among authors: opal sm. Lancet Infect Dis. 2008 Jan;8(1):32-43. doi: 10.1016/S1473-3099(07)70265-7. Epub 2007 Dec 11. Lancet Infect Dis. 2008. PMID: 18063412 Review.
315 results