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Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers.
Rouphael NG, Hurwitz SJ, Hart M, Beck A, Anderson EJ, Deye G, Osborn B, Cai SY, Focht C, Amegashie C, Bowlin TL, Brooks J, Mulligan MJ. Rouphael NG, et al. Among authors: bowlin tl. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00717-19. doi: 10.1128/AAC.00717-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31285228 Free PMC article. Clinical Trial.
Filociclovir Is a Potent In Vitro and In Vivo Inhibitor of Human Adenoviruses.
Toth K, Hussein ITM, Tollefson AE, Ying B, Spencer JF, Eagar J, James SH, Prichard MN, Wold WSM, Bowlin TL. Toth K, et al. Among authors: bowlin tl. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01299-20. doi: 10.1128/AAC.01299-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32816736 Free PMC article.
Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.
Komazin-Meredith G, Chou S, Prichard MN, Hartline CB, Cardinale SC, Comeau K, Williams JD, Khan AR, Peet NP, Bowlin TL. Komazin-Meredith G, et al. Among authors: bowlin tl. Antimicrob Agents Chemother. 2014;58(1):274-8. doi: 10.1128/AAC.01726-13. Epub 2013 Oct 21. Antimicrob Agents Chemother. 2014. PMID: 24145545 Free PMC article.
Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.
James SH, Hartline CB, Harden EA, Driebe EM, Schupp JM, Engelthaler DM, Keim PS, Bowlin TL, Kern ER, Prichard MN. James SH, et al. Among authors: bowlin tl. Antimicrob Agents Chemother. 2011 Oct;55(10):4682-91. doi: 10.1128/AAC.00571-11. Epub 2011 Jul 25. Antimicrob Agents Chemother. 2011. PMID: 21788463 Free PMC article.
156 results