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Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity.
Marshall EE, Malouli D, Hansen SG, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Selseth AN, Ford JC, Burke D, Kreklywich CN, Womack J, Legasse AW, Axthelm MK, Kahl C, Streblow D, Edlefsen PT, Picker LJ, Früh K. Marshall EE, et al. Among authors: womack j. Sci Transl Med. 2019 Jul 17;11(501):eaaw2603. doi: 10.1126/scitranslmed.aaw2603. Sci Transl Med. 2019. PMID: 31316006 Free PMC article.
Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus.
Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K. Sturgill ER, et al. Among authors: womack jl. PLoS Pathog. 2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868. eCollection 2016 Aug. PLoS Pathog. 2016. PMID: 27580123 Free PMC article.
Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge.
Hansen SG, Womack J, Scholz I, Renner A, Edgel KA, Xu G, Ford JC, Grey M, St Laurent B, Turner JM, Planer S, Legasse AW, Richie TL, Aguiar JC, Axthelm MK, Villasante ED, Weiss W, Edlefsen PT, Picker LJ, Früh K. Hansen SG, et al. Among authors: womack j. PLoS One. 2019 Jan 23;14(1):e0210252. doi: 10.1371/journal.pone.0210252. eCollection 2019. PLoS One. 2019. PMID: 30673723 Free PMC article.
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge.
Hansen SG, Marshall EE, Malouli D, Ventura AB, Hughes CM, Ainslie E, Ford JC, Morrow D, Gilbride RM, Bae JY, Legasse AW, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Womack J, Shao J, Edlefsen PT, Reed JS, Burwitz BJ, Sacha JB, Axthelm MK, Früh K, Lifson JD, Picker LJ. Hansen SG, et al. Among authors: womack j. Sci Transl Med. 2019 Jul 17;11(501):eaaw2607. doi: 10.1126/scitranslmed.aaw2607. Sci Transl Med. 2019. PMID: 31316007 Free PMC article.
MHC-E-Restricted CD8+ T Cells Target Hepatitis B Virus-Infected Human Hepatocytes.
Burwitz BJ, Hashiguchi PK, Mansouri M, Meyer C, Gilbride RM, Biswas S, Womack JL, Reed JS, Wu HL, Axthelm MK, Hansen SG, Picker LJ, Früh K, Sacha JB. Burwitz BJ, et al. Among authors: womack jl. J Immunol. 2020 Apr 15;204(8):2169-2176. doi: 10.4049/jimmunol.1900795. Epub 2020 Mar 11. J Immunol. 2020. PMID: 32161099 Free PMC article.
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy.
Verweij MC, Hansen SG, Iyer R, John N, Malouli D, Morrow D, Scholz I, Womack J, Abdulhaqq S, Gilbride RM, Hughes CM, Ventura AB, Ford JC, Selseth AN, Oswald K, Shoemaker R, Berkemeier B, Bosche WJ, Hull M, Shao J, Sacha JB, Axthelm MK, Edlefsen PT, Lifson JD, Picker LJ, Früh K. Verweij MC, et al. Among authors: womack j. Science. 2021 Apr 30;372(6541):eabe9233. doi: 10.1126/science.abe9233. Epub 2021 Mar 25. Science. 2021. PMID: 33766941 Free PMC article.
Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species.
Malouli D, Gilbride RM, Wu HL, Hwang JM, Maier N, Hughes CM, Newhouse D, Morrow D, Ventura AB, Law L, Tisoncik-Go J, Whitmore L, Smith E, Golez I, Chang J, Reed JS, Waytashek C, Weber W, Taher H, Uebelhoer LS, Womack JL, McArdle MR, Gao J, Papen CR, Lifson JD, Burwitz BJ, Axthelm MK, Smedley J, Früh K, Gale M Jr, Picker LJ, Hansen SG, Sacha JB. Malouli D, et al. Among authors: womack jl. Cell Host Microbe. 2022 Sep 14;30(9):1207-1218.e7. doi: 10.1016/j.chom.2022.07.013. Epub 2022 Aug 17. Cell Host Microbe. 2022. PMID: 35981532 Free PMC article.
Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV.
Hansen SG, Womack JL, Perez W, Schmidt KA, Marshall E, Iyer RF, Cleveland Rubeor H, Otero CE, Taher H, Vande Burgt NH, Barfield R, Randall KT, Morrow D, Hughes CM, Selseth AN, Gilbride RM, Ford JC, Caposio P, Tarantal AF, Chan C, Malouli D, Barry PA, Permar SR, Picker LJ, Früh K. Hansen SG, et al. Among authors: womack jl. JCI Insight. 2023 Mar 22;8(6):e164692. doi: 10.1172/jci.insight.164692. JCI Insight. 2023. PMID: 36749635 Free PMC article.
567 results