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Synthesis and initial pharmacology of dual-targeting ligands for putative complexes of integrin αVβ3 and PAR2.
RSC Med Chem. 2020 Jul 9;11(8):940-949. doi: 10.1039/d0md00098a. eCollection 2020 Aug 1.
RSC Med Chem. 2020.
PMID: 33479689
Free PMC article.
β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists.
Rosas R Jr, Huang XP, Roth BL, Dockendorff C.
Rosas R Jr, et al.
ACS Med Chem Lett. 2019 Aug 13;10(9):1353-1356. doi: 10.1021/acsmedchemlett.9b00335. eCollection 2019 Sep 12.
ACS Med Chem Lett. 2019.
PMID: 31531209
Free PMC article.
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The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability.
Gandhi DM, Rosas R Jr, Greve E, Kentala K, D-R Diby N, Snyder VA, Stephans A, Yeung THW, Subramaniam S, DiMilo E, Kurtenbach KE, Arnold LA, Weiler H, Dockendorff C.
Gandhi DM, et al. Among authors: rosas r jr.
Bioorg Med Chem. 2019 Sep 1;27(17):3788-3796. doi: 10.1016/j.bmc.2019.06.043. Epub 2019 Jun 29.
Bioorg Med Chem. 2019.
PMID: 31320211
Free PMC article.
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Design and Evaluation of Heterobivalent PAR1-PAR2 Ligands as Antagonists of Calcium Mobilization.
Majewski MW, Gandhi DM, Rosas R Jr, Kodali R, Arnold LA, Dockendorff C.
Majewski MW, et al. Among authors: rosas r jr.
ACS Med Chem Lett. 2018 Dec 3;10(1):121-126. doi: 10.1021/acsmedchemlett.8b00538. eCollection 2019 Jan 10.
ACS Med Chem Lett. 2018.
PMID: 30655958
Free PMC article.
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Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells.
Gandhi DM, Majewski MW, Rosas R Jr, Kentala K, Foster TJ, Greve E, Dockendorff C.
Gandhi DM, et al. Among authors: rosas r jr.
Bioorg Med Chem. 2018 May 15;26(9):2514-2529. doi: 10.1016/j.bmc.2018.04.016. Epub 2018 Apr 6.
Bioorg Med Chem. 2018.
PMID: 29685684
Free PMC article.
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