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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening.
Boretto M, Maenhoudt N, Luo X, Hennes A, Boeckx B, Bui B, Heremans R, Perneel L, Kobayashi H, Van Zundert I, Brems H, Cox B, Ferrante M, Uji-I H, Koh KP, D'Hooghe T, Vanhie A, Vergote I, Meuleman C, Tomassetti C, Lambrechts D, Vriens J, Timmerman D, Vankelecom H. Boretto M, et al. Among authors: lambrechts d, d hooghe t. Nat Cell Biol. 2019 Aug;21(8):1041-1051. doi: 10.1038/s41556-019-0360-z. Epub 2019 Aug 1. Nat Cell Biol. 2019. PMID: 31371824
High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.
Garcia-Dios DA, Lambrechts D, Coenegrachts L, Vandenput I, Capoen A, Webb PM, Ferguson K; ANECS; Akslen LA, Claes B, Vergote I, Moerman P, Van Robays J, Marcickiewicz J, Salvesen HB, Spurdle AB, Amant F. Garcia-Dios DA, et al. Among authors: lambrechts d. Gynecol Oncol. 2013 Feb;128(2):327-34. doi: 10.1016/j.ygyno.2012.11.037. Epub 2012 Dec 4. Gynecol Oncol. 2013. PMID: 23219661
Genetic changes in nonepithelial ovarian cancer.
Van Nieuwenhuysen E, Lambrechts S, Lambrechts D, Leunen K, Amant F, Vergote I. Van Nieuwenhuysen E, et al. Among authors: lambrechts s, lambrechts d. Expert Rev Anticancer Ther. 2013 Jul;13(7):871-82. doi: 10.1586/14737140.2013.811174. Expert Rev Anticancer Ther. 2013. PMID: 23875665 Review.
Microsatellite instable and microsatellite stable primary endometrial carcinoma cells and their subcutaneous and orthotopic xenografts recapitulate the characteristics of the corresponding primary tumor.
Schrauwen S, Coenegrachts L, Depreeuw J, Luyten C, Verbist G, Debruyne D, Vergote I, Lambrechts D, Amant F. Schrauwen S, et al. Among authors: lambrechts d. Int J Gynecol Cancer. 2015 Mar;25(3):363-71. doi: 10.1097/IGC.0000000000000363. Int J Gynecol Cancer. 2015. PMID: 25695543
Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy.
Despierre E, Vergote I, Anderson R, Coens C, Katsaros D, Hirsch FR, Boeckx B, Varella-Garcia M, Ferrero A, Ray-Coquard I, Berns EM, Casado A, Lambrechts D, Jimeno A; European Organisation for Research and Treatment of Cancer-Gynaecological Cancer Group (EORTC-GCG); Groupe d’Investigateurs Nationaux pour les Etudes des Cancers de l’Ovaire (GINECO); Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (A-AGO); National Cancer Research Institute (NCRI); Australia New Zealand Gynaecological Oncology Group (ANZGOG); Mario Negri Gynecologic Oncology group (MaNGO). Despierre E, et al. Among authors: lambrechts d. Target Oncol. 2015 Dec;10(4):583-96. doi: 10.1007/s11523-015-0369-6. Target Oncol. 2015. PMID: 26004768 Free PMC article. Clinical Trial.
Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies.
Depreeuw J, Hermans E, Schrauwen S, Annibali D, Coenegrachts L, Thomas D, Luyckx M, Gutierrez-Roelens I, Debruyne D, Konings K, Moerman P, Vergote I, Lambrechts D, Amant F. Depreeuw J, et al. Among authors: lambrechts d. Gynecol Oncol. 2015 Oct;139(1):118-26. doi: 10.1016/j.ygyno.2015.07.104. Epub 2015 Jul 29. Gynecol Oncol. 2015. PMID: 26232337
Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers.
Vodolazkaia A, Yesilyurt BT, Kyama CM, Bokor A, Schols D, Huskens D, Meuleman C, Peeraer K, Tomassetti C, Bossuyt X, Lambrechts D, D'Hooghe T, Fassbender A. Vodolazkaia A, et al. Among authors: lambrechts d, d hooghe t. Fertil Steril. 2016 Apr;105(4):988-96. doi: 10.1016/j.fertnstert.2015.12.016. Epub 2016 Jan 7. Fertil Steril. 2016. PMID: 26773192 Free article.
605 results