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Thrombin promotes diet-induced obesity through fibrin-driven inflammation.
Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ. Kopec AK, et al. Among authors: palumbo js. J Clin Invest. 2017 Aug 1;127(8):3152-3166. doi: 10.1172/JCI92744. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737512 Free PMC article.
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.
Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ. Juang LJ, et al. Among authors: palumbo js. Blood. 2022 Mar 3;139(9):1302-1311. doi: 10.1182/blood.2021014559. Blood. 2022. PMID: 34958662 Free PMC article.
New insights into cancer's exploitation of platelets.
Francisco BJ, Palumbo JS. Francisco BJ, et al. Among authors: palumbo js. J Thromb Haemost. 2019 Dec;17(12):2000-2003. doi: 10.1111/jth.14624. J Thromb Haemost. 2019. PMID: 31797541 Free article. No abstract available.
Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
Strilchuk AW, Meixner SC, Leung J, Safikhan NS, Kulkarni JA, Russell HM, van der Meel R, Sutherland MR, Owens AP, Palumbo JS, Conway EM, Pryzdial ELG, Cullis PR, Kastrup CJ. Strilchuk AW, et al. Among authors: palumbo js. Blood. 2020 Dec 17;136(25):2946-2954. doi: 10.1182/blood.2020004976. Blood. 2020. PMID: 32678423 Free PMC article.
Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.
Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS. Steinbrecher KA, et al. Among authors: palumbo js. Cancer Res. 2010 Apr 1;70(7):2634-43. doi: 10.1158/0008-5472.CAN-09-3465. Epub 2010 Mar 16. Cancer Res. 2010. PMID: 20233870 Free PMC article.
91 results