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The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG. Hallin J, et al. Among authors: hargis l. Cancer Discov. 2020 Jan;10(1):54-71. doi: 10.1158/2159-8290.CD-19-1167. Epub 2019 Oct 28. Cancer Discov. 2020. PMID: 31658955 Free PMC article.
The KRASG12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy.
Briere DM, Li S, Calinisan A, Sudhakar N, Aranda R, Hargis L, Peng DH, Deng J, Engstrom LD, Hallin J, Gatto S, Fernandez-Banet J, Pavlicek A, Wong KK, Christensen JG, Olson P. Briere DM, et al. Among authors: hargis l. Mol Cancer Ther. 2021 Jun;20(6):975-985. doi: 10.1158/1535-7163.MCT-20-0462. Epub 2021 Mar 15. Mol Cancer Ther. 2021. PMID: 33722854 Free PMC article.
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor.
Hallin J, Bowcut V, Calinisan A, Briere DM, Hargis L, Engstrom LD, Laguer J, Medwid J, Vanderpool D, Lifset E, Trinh D, Hoffman N, Wang X, David Lawson J, Gunn RJ, Smith CR, Thomas NC, Martinson M, Bergstrom A, Sullivan F, Bouhana K, Winski S, He L, Fernandez-Banet J, Pavlicek A, Haling JR, Rahbaek L, Marx MA, Olson P, Christensen JG. Hallin J, et al. Among authors: hargis l. Nat Med. 2022 Oct;28(10):2171-2182. doi: 10.1038/s41591-022-02007-7. Epub 2022 Oct 10. Nat Med. 2022. PMID: 36216931
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, MacRae NS, DeMeester KE, Njomen E, Hargis LM, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: hargis lm. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586158. doi: 10.1101/2024.03.21.586158. bioRxiv. 2024. PMID: 38562719 Free PMC article. Preprint.
Ultraviolet and light absorption spectrometry.
Howell JA, Hargis LG. Howell JA, et al. Among authors: hargis lg. Anal Chem. 1994 Jun 15;66(12):445R-461R. doi: 10.1021/ac00084a017. Anal Chem. 1994. PMID: 8092474 Review. No abstract available.
Ultraviolet and light absorption spectrometry.
Howell JA, Hargis LG. Howell JA, et al. Among authors: hargis lg. Anal Chem. 1990 Jun;62(12):155R-69R. doi: 10.1021/ac00211a006. Anal Chem. 1990. PMID: 20527849 No abstract available.
Ultraviolet and light absorption spectrometry.
Hargis LG, Howell JA. Hargis LG, et al. Anal Chem. 1988 Jun 15;60(12):131R-146R. doi: 10.1021/ac00163a010. Anal Chem. 1988. PMID: 3046418 Review. No abstract available.