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Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences.
Lippert J, Burghaus R, Edginton A, Frechen S, Karlsson M, Kovar A, Lehr T, Milligan P, Nock V, Ramusovic S, Riggs M, Schaller S, Schlender J, Schmidt S, Sevestre M, Sjögren E, Solodenko J, Staab A, Teutonico D. Lippert J, et al. Among authors: sjogren e. CPT Pharmacometrics Syst Pharmacol. 2019 Dec;8(12):878-882. doi: 10.1002/psp4.12473. Epub 2019 Nov 12. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31671256 Free PMC article. Review. No abstract available.
Does the choice of applied physiologically-based pharmacokinetics platform matter? A case study on simvastatin disposition and drug-drug interaction.
Prieto Garcia L, Lundahl A, Ahlström C, Vildhede A, Lennernäs H, Sjögren E. Prieto Garcia L, et al. Among authors: sjogren e. CPT Pharmacometrics Syst Pharmacol. 2022 Sep;11(9):1194-1209. doi: 10.1002/psp4.12837. Epub 2022 Jul 16. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35722750 Free PMC article.
Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins.
Prieto Garcia L, Vildhede A, Nordell P, Ahlström C, Montaser AB, Terasaki T, Lennernäs H, Sjögren E. Prieto Garcia L, et al. Among authors: sjogren e. CPT Pharmacometrics Syst Pharmacol. 2024 Apr 4. doi: 10.1002/psp4.13139. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38576225 Free article.
The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations.
Sjögren E, Lennernäs H, Andersson TB, Gråsjö J, Bredberg U. Sjögren E, et al. Drug Metab Dispos. 2009 Jan;37(1):47-58. doi: 10.1124/dmd.108.021477. Epub 2008 Sep 29. Drug Metab Dispos. 2009. PMID: 18824525
Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.
Arvidsson B, Allard E, Sjögren E, Lennernäs H, Sjöberg PJ, Bergquist J. Arvidsson B, et al. Among authors: sjogren e. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):291-7. doi: 10.1016/j.jchromb.2008.12.017. Epub 2008 Dec 11. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19117807
195 results