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Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, Grosenbach DW. Berhanu A, et al. Among authors: silvera pm. Antimicrob Agents Chemother. 2015 Jul;59(7):4296-300. doi: 10.1128/AAC.00208-15. Epub 2015 Apr 20. Antimicrob Agents Chemother. 2015. PMID: 25896687 Free PMC article.
Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys.
Zielinski RJ, Smedley JV, Perera PY, Silvera PM, Waldmann TA, Capala J, Perera LP. Zielinski RJ, et al. Among authors: silvera pm. Vaccine. 2010 Oct 8;28(43):7081-91. doi: 10.1016/j.vaccine.2010.08.008. Epub 2010 Aug 20. Vaccine. 2010. PMID: 20728526 Free PMC article.
Subunit recombinant vaccine protects against monkeypox.
Heraud JM, Edghill-Smith Y, Ayala V, Kalisz I, Parrino J, Kalyanaraman VS, Manischewitz J, King LR, Hryniewicz A, Trindade CJ, Hassett M, Tsai WP, Venzon D, Nalca A, Vaccari M, Silvera P, Bray M, Graham BS, Golding H, Hooper JW, Franchini G. Heraud JM, et al. J Immunol. 2006 Aug 15;177(4):2552-64. doi: 10.4049/jimmunol.177.4.2552. J Immunol. 2006. PMID: 16888017
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