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Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.
Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F. Machado-Neto JA, et al. Among authors: traina f. Cell Death Dis. 2018 Feb 22;9(3):311. doi: 10.1038/s41419-017-0256-4. Cell Death Dis. 2018. PMID: 29472557 Free PMC article.
NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia.
Scopim-Ribeiro R, Machado-Neto JA, Eide CA, Coelho-Silva JL, Fenerich BA, Fernandes JC, Scheucher PS, Savage Stevens SL, de Melo Campos P, Olalla Saad ST, de Carvalho Palma L, de Figueiredo-Pontes LL, Simões BP, Rego EM, Tognon CE, Druker BJ, Traina F. Scopim-Ribeiro R, et al. Among authors: traina f. Invest New Drugs. 2021 Jun;39(3):736-746. doi: 10.1007/s10637-020-01028-8. Epub 2021 Jan 6. Invest New Drugs. 2021. PMID: 33403501
STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
Vicari HP, Coelho-Silva JL, Pereira-Martins DA, Lucena-Araujo AR, Lima K, Lipreri da Silva JC, Scheucher PS, Koury LC, de Melo RA, Bittencourt R, Pagnano K, Nunes E, Fagundes EM, Kerbauy F, de Figueiredo-Pontes LL, Costa-Lotufo LV, Rego EM, Traina F, Machado-Neto JA. Vicari HP, et al. Among authors: traina f. Invest New Drugs. 2022 Apr;40(2):438-452. doi: 10.1007/s10637-021-01197-0. Epub 2021 Nov 27. Invest New Drugs. 2022. PMID: 34837603
Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model.
Alves-Silva AB, Fenerich BA, Fonseca NP, Fernandes JC, Coelho-Silva JL, Pereira-Martins DA, Bianco TM, Scheucher PS, Rego EM, Chahud F, Machado-Neto JA, Figueiredo-Pontes LL, Traina F. Alves-Silva AB, et al. Among authors: traina f. Invest New Drugs. 2022 Jun;40(3):576-585. doi: 10.1007/s10637-022-01212-y. Epub 2022 Jan 11. Invest New Drugs. 2022. PMID: 35015172
Identification of target genes using gene expression profile of granulocytes from patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors.
Mascarenhas Cdo C, Ferreira da Cunha A, Brugnerotto AF, Gambero S, de Almeida MH, Carazzolle MF, Pagnano KB, Traina F, Costa FF, de Souza CA. Mascarenhas Cdo C, et al. Among authors: traina f. Leuk Lymphoma. 2014 Aug;55(8):1861-9. doi: 10.3109/10428194.2013.855311. Epub 2014 Feb 4. Leuk Lymphoma. 2014. PMID: 24144310
Clinical features of JAK2V617F- or CALR-mutated essential thrombocythemia and primary myelofibrosis.
Monte-Mor Bda C, Ayres-Silva Jde P, Correia WD, Coelho AC, Solza C, Daumas AH, Bonamino MH, Santos FP, Datoguia TS, Pereira Wde O, Lisboa BC, Ramos CF, Machado-Neto JA, Hamerschlak N, Campregher PV, Traina F, Pagnano KB, Zalcberg I. Monte-Mor Bda C, et al. Among authors: traina f. Blood Cells Mol Dis. 2016 Sep;60:74-7. doi: 10.1016/j.bcmd.2016.03.003. Epub 2016 Mar 8. Blood Cells Mol Dis. 2016. PMID: 26994960 Clinical Trial. No abstract available.
Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.
Pereira-Martins DA, Coelho-Silva JL, Weinhäuser I, Franca-Neto PL, Silveira DR, Ortiz C, Moreira-Aguiar A, Lima MM, Koury LC, de Melo RA, Glória AB, Fagundes EM, Lino BK, Pagnano K, Bittencourt R, Nunes E, Traina F, Figueiredo-Pontes L, Keating A, Tallman MS, Ribeiro RC, Dilon R, Ganser A, Sanz MA, Berliner N, Valk P, Löwenberg B, Ottone T, Noguera NI, Voso MT, Paoloni F, Fazi P, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Lucena-Araujo AR. Pereira-Martins DA, et al. Among authors: traina f. Br J Haematol. 2023 Jan;200(2):170-174. doi: 10.1111/bjh.18510. Epub 2022 Oct 20. Br J Haematol. 2023. PMID: 36263593
342 results