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Live Respiratory Syncytial Virus Attenuated by M2-2 Deletion and Stabilized Temperature Sensitivity Mutation 1030s Is a Promising Vaccine Candidate in Children.
McFarland EJ, Karron RA, Muresan P, Cunningham CK, Libous J, Perlowski C, Thumar B, Gnanashanmugam D, Moye J, Schappell E, Barr E, Rexroad V, Fearn L, Spector SA, Aziz M, Cielo M, Beneri C, Wiznia A, Luongo C, Collins P, Buchholz UJ. McFarland EJ, et al. Among authors: luongo c. J Infect Dis. 2020 Feb 3;221(4):534-543. doi: 10.1093/infdis/jiz603. J Infect Dis. 2020. PMID: 31758177 Free PMC article. Clinical Trial.
A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction.
Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE Jr, Goleniewska K, Williams JV, Collins PL, Peebles RS Jr. Moore ML, et al. Among authors: luongo c. J Virol. 2009 May;83(9):4185-94. doi: 10.1128/JVI.01853-08. Epub 2009 Feb 11. J Virol. 2009. PMID: 19211758 Free PMC article.
Respiratory syncytial virus modified by deletions of the NS2 gene and amino acid S1313 of the L polymerase protein is a temperature-sensitive, live-attenuated vaccine candidate that is phenotypically stable at physiological temperature.
Luongo C, Winter CC, Collins PL, Buchholz UJ. Luongo C, et al. J Virol. 2013 Feb;87(4):1985-96. doi: 10.1128/JVI.02769-12. Epub 2012 Dec 12. J Virol. 2013. PMID: 23236065 Free PMC article.
In previous work to develop point mutations in RSV with improved genetic stability, we observed that an attenuating mutation at amino acid position 1321 in the L polymerase protein was subject to deattenuation by a spontaneous second-site compensatory mutation at position 1313 ( …
In previous work to develop point mutations in RSV with improved genetic stability, we observed that an attenuating mutation at amino acid p …
Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization.
Le Nouën C, Brock LG, Luongo C, McCarty T, Yang L, Mehedi M, Wimmer E, Mueller S, Collins PL, Buchholz UJ, DiNapoli JM. Le Nouën C, et al. Among authors: luongo c. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13169-74. doi: 10.1073/pnas.1411290111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157129 Free PMC article.
178 results