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207 results

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Page 1
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Winneroski LL, Erickson JA, Green SJ, Lopez JE, Stout SL, Porter WJ, Timm DE, Audia JE, Barberis M, Beck JP, Boggs LN, Borders AR, Boyer RD, Brier RA, Hembre EJ, Hendle J, Garcia-Losada P, Minguez JM, Mathes BM, May PC, Monk SA, Rankovic Z, Shi Y, Watson BM, Yang Z, Mergott DJ. Winneroski LL, et al. Among authors: lopez je. Bioorg Med Chem. 2020 Jan 1;28(1):115194. doi: 10.1016/j.bmc.2019.115194. Epub 2019 Nov 15. Bioorg Med Chem. 2020. PMID: 31786008
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
McKinzie DL, Winneroski LL, Green SJ, Hembre EJ, Erickson JA, Willis BA, Monk SA, Aluise CD, Baker TK, Lopez JE, Hendle J, Beck JP, Brier RA, Boggs LN, Borders AR, Cocke PJ, Garcia-Losada P, Lowe SL, Mathes BM, May PC, Porter WJ, Stout SL, Timm DE, Watson BM, Yang Z, Mergott DJ. McKinzie DL, et al. Among authors: lopez je. J Med Chem. 2021 Jun 24;64(12):8076-8100. doi: 10.1021/acs.jmedchem.1c00489. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34081466
Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.
Lobb KL, Hipskind PA, Aikins JA, Alvarez E, Cheung YY, Considine EL, De Dios A, Durst GL, Ferritto R, Grossman CS, Giera DD, Hollister BA, Huang Z, Iversen PW, Law KL, Li T, Lin HS, Lopez B, Lopez JE, Cabrejas LM, McCann DJ, Molero V, Reilly JE, Richett ME, Shih C, Teicher B, Wikel JH, White WT, Mader MM. Lobb KL, et al. Among authors: lopez b, lopez je. J Med Chem. 2004 Oct 21;47(22):5367-80. doi: 10.1021/jm030594r. J Med Chem. 2004. PMID: 15481975
Acyl sulfonamide anti-proliferatives. Part 2: activity of heterocyclic sulfonamide derivatives.
Mader MM, Shih C, Considine E, Dios AD, Grossman CS, Hipskind PA, Lin HS, Lobb KL, Lopez B, Lopez JE, Cabrejas LM, Richett ME, White WT, Cheung YY, Huang Z, Reilly JE, Dinn SR. Mader MM, et al. Among authors: lopez b, lopez je. Bioorg Med Chem Lett. 2005 Feb 1;15(3):617-20. doi: 10.1016/j.bmcl.2004.11.041. Bioorg Med Chem Lett. 2005. PMID: 15664824
Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.
Richardson TI, Clarke CA, Yu KL, Yee YK, Bleisch TJ, Lopez JE, Jones SA, Hughes NE, Muehl BS, Lugar CW, Moore TL, Shetler PK, Zink RW, Osborne JJ, Montrose-Rafizadeh C, Patel N, Geiser AG, Galvin RJ, Dodge JA. Richardson TI, et al. Among authors: lopez je. ACS Med Chem Lett. 2010 Dec 9;2(2):148-53. doi: 10.1021/ml100220b. eCollection 2011 Feb 10. ACS Med Chem Lett. 2010. PMID: 24900294 Free PMC article.
Association of Neighborhood and Environmental Factors with Clinical Phenotypes and Outcomes in Heart Failure with Preserved Ejection Fraction.
Liem DA, Olivera da Silva H, Romero E, Rocha P, Acevedo PE, Izu M, Ballal A, Soroya S, Lopez JE, Nuno MA, Quazi A, Mukherjee C, Linklater WL, Ebong I, Zhang XD, Izu L, Sirish P, Chiamvimonvat N, Cadeiras M. Liem DA, et al. Among authors: lopez je. Circ Res. 2024 May 17. doi: 10.1161/CIRCRESAHA.124.324429. Online ahead of print. Circ Res. 2024. PMID: 38759107 Review. No abstract available.
Development of PainFace software to simplify, standardize, and scale up mouse grimace analyses.
McCoy ES, Park SK, Patel RP, Ryan DF, Mullen ZJ, Nesbitt JJ, Lopez JE, Taylor-Blake B, Vanden KA, Krantz JL, Hu W, Garris RL, Snyder MG, Lima LV, Sotocinal SG, Austin JS, Kashlan AD, Shah S, Trocinski AK, Pudipeddi SS, Major RM, Bazick HO, Klein MR, Mogil JS, Wu G, Zylka MJ. McCoy ES, et al. Among authors: lopez je. Pain. 2024 Feb 13. doi: 10.1097/j.pain.0000000000003187. Online ahead of print. Pain. 2024. PMID: 38345524
Borrelia turicatae from Ticks in Peridomestic Setting, Camayeca, Mexico.
Vázquez-Guerrero E, Kneubehl AR, Pellegrini-Hernández P, González-Quiroz JL, Domínguez-López ML, Krishnavajhala A, Estrada-de Los Santos P, Ibarra JA, Lopez JE. Vázquez-Guerrero E, et al. Among authors: lopez je. Emerg Infect Dis. 2024 Feb;30(2):380-383. doi: 10.3201/eid3002.231053. Emerg Infect Dis. 2024. PMID: 38270112 Free PMC article.
207 results