Chen Q - Search Results

1

Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli.

Beyett TS, Chen Q, Labudde EJ, Krampen J, Sharma PV, Tesmer JJG. Beyett TS, et al. Among authors: chen q. Protein Expr Purif. 2020 Apr;168:105547. doi: 10.1016/j.pep.2019.105547. Epub 2019 Nov 29. Protein Expr Purif. 2020. PMID: 31786308 Free PMC article.

2

G protein-coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias.

Chen Q, Tesmer JJG. Chen Q, et al. J Biol Chem. 2022 Sep;298(9):102279. doi: 10.1016/j.jbc.2022.102279. Epub 2022 Jul 19. J Biol Chem. 2022. PMID: 35863432 Free PMC article. Review.

3

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.

Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG. Beyett TS, et al. Among authors: chen q. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15895-15900. doi: 10.1073/pnas.1818547116. Epub 2019 Jul 23. Proc Natl Acad Sci U S A. 2019. PMID: 31337679 Free PMC article.

4

Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

Rowlands RA, Chen Q, Bouley RA, Avramova LV, Tesmer JJG, White AD. Rowlands RA, et al. Among authors: chen q. J Med Chem. 2021 Jan 14;64(1):566-585. doi: 10.1021/acs.jmedchem.0c01522. Epub 2021 Jan 4. J Med Chem. 2021. PMID: 33393767 Free PMC article.

5

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.

Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG. Chen Q, et al. Among authors: chen cl. Nature. 2021 Jul;595(7868):600-605. doi: 10.1038/s41586-021-03721-x. Epub 2021 Jul 14. Nature. 2021. PMID: 34262173 Free PMC article.

6

A Receptor on Acid.

Chen Q, Tesmer JJG. Chen Q, et al. Cell. 2017 Jan 26;168(3):339-341. doi: 10.1016/j.cell.2017.01.012. Cell. 2017. PMID: 28129534 Free PMC article.

7

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.

Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD. Rowlands RA, et al. Among authors: chen q. ACS Med Chem Lett. 2019 Nov 12;10(12):1628-1634. doi: 10.1021/acsmedchemlett.9b00365. eCollection 2019 Dec 12. ACS Med Chem Lett. 2019. PMID: 31857838 Free PMC article.

8

Structural Basis of Arrestin-Dependent Signal Transduction.

Chen Q, Iverson TM, Gurevich VV. Chen Q, et al. Trends Biochem Sci. 2018 Jun;43(6):412-423. doi: 10.1016/j.tibs.2018.03.005. Epub 2018 Apr 7. Trends Biochem Sci. 2018. PMID: 29636212 Free PMC article. Review.

9

An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins.

Chen Q, Zhuo Y, Sharma P, Perez I, Francis DJ, Chakravarthy S, Vishnivetskiy SA, Berndt S, Hanson SM, Zhan X, Brooks EK, Altenbach C, Hubbell WL, Klug CS, Iverson TM, Gurevich VV. Chen Q, et al. J Mol Biol. 2021 Feb 19;433(4):166790. doi: 10.1016/j.jmb.2020.166790. Epub 2020 Dec 31. J Mol Biol. 2021. PMID: 33387531 Free PMC article.

10

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification.

Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV. Perry NA, et al. Among authors: chen q. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):810-815. doi: 10.1073/pnas.1819230116. Epub 2018 Dec 27. Proc Natl Acad Sci U S A. 2019. PMID: 30591558 Free PMC article.

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