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Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.
van de Sandt CE, Clemens EB, Grant EJ, Rowntree LC, Sant S, Halim H, Crowe J, Cheng AC, Kotsimbos TC, Richards M, Miller A, Tong SYC, Rossjohn J, Nguyen THO, Gras S, Chen W, Kedzierska K. van de Sandt CE, et al. Among authors: crowe j. Nat Commun. 2019 Dec 6;10(1):5579. doi: 10.1038/s41467-019-13346-4. Nat Commun. 2019. PMID: 31811120 Free PMC article.
Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation.
Loh L, Wang Z, Sant S, Koutsakos M, Jegaskanda S, Corbett AJ, Liu L, Fairlie DP, Crowe J, Rossjohn J, Xu J, Doherty PC, McCluskey J, Kedzierska K. Loh L, et al. Among authors: crowe j. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10133-8. doi: 10.1073/pnas.1610750113. Epub 2016 Aug 19. Proc Natl Acad Sci U S A. 2016. PMID: 27543331 Free PMC article.
Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly.
Nguyen THO, Sant S, Bird NL, Grant EJ, Clemens EB, Koutsakos M, Valkenburg SA, Gras S, Lappas M, Jaworowski A, Crowe J, Loh L, Kedzierska K. Nguyen THO, et al. Among authors: crowe j. J Leukoc Biol. 2018 Feb;103(2):321-339. doi: 10.1189/jlb.5MA0517-207R. Epub 2017 Dec 29. J Leukoc Biol. 2018. PMID: 28928269
Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection.
Sant S, Grzelak L, Wang Z, Pizzolla A, Koutsakos M, Crowe J, Loudovaris T, Mannering SI, Westall GP, Wakim LM, Rossjohn J, Gras S, Richards M, Xu J, Thomas PG, Loh L, Nguyen THO, Kedzierska K. Sant S, et al. Among authors: crowe j. Front Immunol. 2018 Jun 27;9:1453. doi: 10.3389/fimmu.2018.01453. eCollection 2018. Front Immunol. 2018. PMID: 29997621 Free PMC article.
Human γδ T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation.
Sant S, Jenkins MR, Dash P, Watson KA, Wang Z, Pizzolla A, Koutsakos M, Nguyen TH, Lappas M, Crowe J, Loudovaris T, Mannering SI, Westall GP, Kotsimbos TC, Cheng AC, Wakim L, Doherty PC, Thomas PG, Loh L, Kedzierska K. Sant S, et al. Among authors: crowe j. Clin Transl Immunology. 2019 Sep 23;8(9):e1079. doi: 10.1002/cti2.1079. eCollection 2019. Clin Transl Immunology. 2019. PMID: 31559018 Free PMC article.
Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses.
Loh L, Gherardin NA, Sant S, Grzelak L, Crawford JC, Bird NL, Koay HF, van de Sandt CE, Moreira ML, Lappas M, Allen EK, Crowe J, Loudovaris T, Flanagan KL, Quinn KM, Rossjohn J, Thomas PG, Eckle SBG, McCluskey J, Godfrey DI, Kedzierska K. Loh L, et al. Among authors: crowe j. J Immunol. 2020 Mar 1;204(5):1119-1133. doi: 10.4049/jimmunol.1900774. Epub 2020 Jan 27. J Immunol. 2020. PMID: 31988181 Clinical Trial.
HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells.
Sant S, Quiñones-Parra SM, Koutsakos M, Grant EJ, Loudovaris T, Mannering SI, Crowe J, van de Sandt CE, Rimmelzwaan GF, Rossjohn J, Gras S, Loh L, Nguyen THO, Kedzierska K. Sant S, et al. Among authors: crowe j. PLoS Pathog. 2020 Aug 4;16(8):e1008714. doi: 10.1371/journal.ppat.1008714. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32750095 Free PMC article.
Systems serology detects functionally distinct coronavirus antibody features in children and elderly.
Selva KJ, van de Sandt CE, Lemke MM, Lee CY, Shoffner SK, Chua BY, Davis SK, Nguyen THO, Rowntree LC, Hensen L, Koutsakos M, Wong CY, Mordant F, Jackson DC, Flanagan KL, Crowe J, Tosif S, Neeland MR, Sutton P, Licciardi PV, Crawford NW, Cheng AC, Doolan DL, Amanat F, Krammer F, Chappell K, Modhiran N, Watterson D, Young P, Lee WS, Wines BD, Mark Hogarth P, Esterbauer R, Kelly HG, Tan HX, Juno JA, Wheatley AK, Kent SJ, Arnold KB, Kedzierska K, Chung AW. Selva KJ, et al. Among authors: crowe j. Nat Commun. 2021 Apr 1;12(1):2037. doi: 10.1038/s41467-021-22236-7. Nat Commun. 2021. PMID: 33795692 Free PMC article.
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients.
Nguyen THO, Koutsakos M, van de Sandt CE, Crawford JC, Loh L, Sant S, Grzelak L, Allen EK, Brahm T, Clemens EB, Auladell M, Hensen L, Wang Z, Nüssing S, Jia X, Günther P, Wheatley AK, Kent SJ, Aban M, Deng YM, Laurie KL, Hurt AC, Gras S, Rossjohn J, Crowe J, Xu J, Jackson D, Brown LE, La Gruta N, Chen W, Doherty PC, Turner SJ, Kotsimbos TC, Thomas PG, Cheng AC, Kedzierska K. Nguyen THO, et al. Among authors: crowe j. Nat Commun. 2021 May 11;12(1):2691. doi: 10.1038/s41467-021-23018-x. Nat Commun. 2021. PMID: 33976217 Free PMC article.
Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan.
van de Sandt CE, Nguyen THO, Gherardin NA, Crawford JC, Samir J, Minervina AA, Pogorelyy MV, Rizzetto S, Szeto C, Kaur J, Ranson N, Sonda S, Harper A, Redmond SJ, McQuilten HA, Menon T, Sant S, Jia X, Pedrina K, Karapanagiotidis T, Cain N, Nicholson S, Chen Z, Lim R, Clemens EB, Eltahla A, La Gruta NL, Crowe J, Lappas M, Rossjohn J, Godfrey DI, Thomas PG, Gras S, Flanagan KL, Luciani F, Kedzierska K. van de Sandt CE, et al. Among authors: crowe j. Nat Immunol. 2023 Nov;24(11):1890-1907. doi: 10.1038/s41590-023-01633-8. Epub 2023 Sep 25. Nat Immunol. 2023. PMID: 37749325 Free PMC article.
1,218 results