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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
Blumberg LJ, Humphries JE, Jones SD, Pearce LB, Holgate R, Hearn A, Cheung J, Mahmood A, Del Tito B, Graydon JS, Stolz LE, Bitonti A, Purohit S, de Graaf D, Kacena K, Andersen JT, Christianson GJ, Roopenian DC, Hubbard JJ, Gandhi AK, Lasseter K, Pyzik M, Blumberg RS. Blumberg LJ, et al. Among authors: andersen jt. Sci Adv. 2019 Dec 18;5(12):eaax9586. doi: 10.1126/sciadv.aax9586. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31897428 Free PMC article. Clinical Trial.
Dependence of antibody-mediated presentation of antigen on FcRn.
Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, Blumberg RS. Qiao SW, et al. Among authors: andersen jt. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42. doi: 10.1073/pnas.0801717105. Epub 2008 Jul 1. Proc Natl Acad Sci U S A. 2008. PMID: 18599440 Free PMC article.
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Baker K, et al. Among authors: andersen jt. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32. doi: 10.1073/pnas.1019037108. Epub 2011 May 31. Proc Natl Acad Sci U S A. 2011. PMID: 21628593 Free PMC article.
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life.
Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I. Andersen JT, et al. J Biol Chem. 2012 Jun 29;287(27):22927-37. doi: 10.1074/jbc.M112.355131. Epub 2012 May 8. J Biol Chem. 2012. PMID: 22570488 Free PMC article.
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J. Andersen JT, et al. J Biol Chem. 2014 May 9;289(19):13492-502. doi: 10.1074/jbc.M114.549832. Epub 2014 Mar 20. J Biol Chem. 2014. PMID: 24652290 Free PMC article.
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Pyzik M, et al. Among authors: andersen jt. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22. Proc Natl Acad Sci U S A. 2017. PMID: 28330995 Free PMC article.
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.
Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT. Grevys A, et al. Among authors: andersen jt. Nat Commun. 2018 Feb 12;9(1):621. doi: 10.1038/s41467-018-03061-x. Nat Commun. 2018. PMID: 29434196 Free PMC article.
356 results