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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
Blumberg LJ, Humphries JE, Jones SD, Pearce LB, Holgate R, Hearn A, Cheung J, Mahmood A, Del Tito B, Graydon JS, Stolz LE, Bitonti A, Purohit S, de Graaf D, Kacena K, Andersen JT, Christianson GJ, Roopenian DC, Hubbard JJ, Gandhi AK, Lasseter K, Pyzik M, Blumberg RS. Blumberg LJ, et al. Sci Adv. 2019 Dec 18;5(12):eaax9586. doi: 10.1126/sciadv.aax9586. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31897428 Free PMC article. Clinical Trial.
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Cines DB, Zaitsev S, Rauova L, Rux AH, Stepanova V, Krishnaswamy S, Sarkar A, Kowalska MA, Zhao G, Mast AE, Blumberg LJ, McCrae KR, Poncz M, Hubbard JJ, Pyzik M, Blumberg RS. Cines DB, et al. Among authors: blumberg lj. Blood. 2020 Jun 4;135(23):2085-2093. doi: 10.1182/blood.2019001133. Blood. 2020. PMID: 32187355 Free PMC article.
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Pyzik M, et al. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22. Proc Natl Acad Sci U S A. 2017. PMID: 28330995 Free PMC article.
The Individual Market: The Authors Reply.
Corlette S, Lucia K, Blumberg LJ. Corlette S, et al. Among authors: blumberg lj. Health Aff (Millwood). 2020 May;39(5):907. doi: 10.1377/hlthaff.2020.00356. Health Aff (Millwood). 2020. PMID: 32364868 No abstract available.
The ACA's Effect On The Individual Insurance Market.
Corlette S, Blumberg LJ, Lucia K. Corlette S, et al. Among authors: blumberg lj. Health Aff (Millwood). 2020 Mar;39(3):436-444. doi: 10.1377/hlthaff.2019.01363. Health Aff (Millwood). 2020. PMID: 32119609
Strengthening the ACA for the Long Term.
Blumberg LJ, Holahan J. Blumberg LJ, et al. N Engl J Med. 2017 Nov 30;377(22):2105-2107. doi: 10.1056/NEJMp1713247. Epub 2017 Oct 18. N Engl J Med. 2017. PMID: 29045195 No abstract available.
35 results