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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
Blumberg LJ, Humphries JE, Jones SD, Pearce LB, Holgate R, Hearn A, Cheung J, Mahmood A, Del Tito B, Graydon JS, Stolz LE, Bitonti A, Purohit S, de Graaf D, Kacena K, Andersen JT, Christianson GJ, Roopenian DC, Hubbard JJ, Gandhi AK, Lasseter K, Pyzik M, Blumberg RS. Blumberg LJ, et al. Among authors: blumberg rs. Sci Adv. 2019 Dec 18;5(12):eaax9586. doi: 10.1126/sciadv.aax9586. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31897428 Free PMC article. Clinical Trial.
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, Blumberg RS. Yoshida M, et al. Among authors: blumberg rs. J Clin Invest. 2006 Aug;116(8):2142-2151. doi: 10.1172/JCI27821. J Clin Invest. 2006. PMID: 16841095 Free PMC article.
Dependence of antibody-mediated presentation of antigen on FcRn.
Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, Blumberg RS. Qiao SW, et al. Among authors: blumberg rs. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42. doi: 10.1073/pnas.0801717105. Epub 2008 Jul 1. Proc Natl Acad Sci U S A. 2008. PMID: 18599440 Free PMC article.
Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.
Baker K, Qiao SW, Kuo T, Kobayashi K, Yoshida M, Lencer WI, Blumberg RS. Baker K, et al. Among authors: blumberg rs. Semin Immunopathol. 2009 Jul;31(2):223-36. doi: 10.1007/s00281-009-0160-9. Epub 2009 Jun 3. Semin Immunopathol. 2009. PMID: 19495758 Free PMC article. Review.
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS. Baker K, et al. Among authors: blumberg rs. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9927-32. doi: 10.1073/pnas.1019037108. Epub 2011 May 31. Proc Natl Acad Sci U S A. 2011. PMID: 21628593 Free PMC article.
365 results