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Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity.
Shapiro MB, Cheever T, Malherbe DC, Pandey S, Reed J, Yang ES, Wang K, Pegu A, Chen X, Siess D, Burke D, Henderson H, Lewinsohn R, Fischer M, Stanton JJ, Axthelm MK, Kahl C, Park B, Lewis AD, Sacha JB, Mascola JR, Hessell AJ, Haigwood NL. Shapiro MB, et al. Among authors: mascola jr. Nat Commun. 2020 Jan 7;11(1):70. doi: 10.1038/s41467-019-13972-y. Nat Commun. 2020. PMID: 31911610 Free PMC article.
Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccines.
Mascola JR, D'Souza P, Gilbert P, Hahn BH, Haigwood NL, Morris L, Petropoulos CJ, Polonis VR, Sarzotti M, Montefiori DC. Mascola JR, et al. J Virol. 2005 Aug;79(16):10103-7. doi: 10.1128/JVI.79.16.10103-10107.2005. J Virol. 2005. PMID: 16051803 Free PMC article. No abstract available.
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR. Li Y, et al. Among authors: mascola jr. Nat Med. 2007 Sep;13(9):1032-4. doi: 10.1038/nm1624. Epub 2007 Aug 26. Nat Med. 2007. PMID: 17721546 Free PMC article.
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.
Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC. Scheid JF, et al. Among authors: mascola jr. Nature. 2009 Apr 2;458(7238):636-40. doi: 10.1038/nature07930. Epub 2009 Mar 15. Nature. 2009. PMID: 19287373
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.
Chen L, Kwon YD, Zhou T, Wu X, O'Dell S, Cavacini L, Hessell AJ, Pancera M, Tang M, Xu L, Yang ZY, Zhang MY, Arthos J, Burton DR, Dimitrov DS, Nabel GJ, Posner MR, Sodroski J, Wyatt R, Mascola JR, Kwong PD. Chen L, et al. Among authors: mascola jr. Science. 2009 Nov 20;326(5956):1123-7. doi: 10.1126/science.1175868. Science. 2009. PMID: 19965434 Free PMC article.
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
Roederer M, Keele BF, Schmidt SD, Mason RD, Welles HC, Fischer W, Labranche C, Foulds KE, Louder MK, Yang ZY, Todd JP, Buzby AP, Mach LV, Shen L, Seaton KE, Ward BM, Bailer RT, Gottardo R, Gu W, Ferrari G, Alam SM, Denny TN, Montefiori DC, Tomaras GD, Korber BT, Nason MC, Seder RA, Koup RA, Letvin NL, Rao SS, Nabel GJ, Mascola JR. Roederer M, et al. Among authors: mascola jr. Nature. 2014 Jan 23;505(7484):502-8. doi: 10.1038/nature12893. Epub 2013 Dec 18. Nature. 2014. PMID: 24352234 Free PMC article.
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.
Pegu A, Yang ZY, Boyington JC, Wu L, Ko SY, Schmidt SD, McKee K, Kong WP, Shi W, Chen X, Todd JP, Letvin NL, Huang J, Nason MC, Hoxie JA, Kwong PD, Connors M, Rao SS, Mascola JR, Nabel GJ. Pegu A, et al. Among authors: mascola jr. Sci Transl Med. 2014 Jul 2;6(243):243ra88. doi: 10.1126/scitranslmed.3008992. Sci Transl Med. 2014. PMID: 24990883 Free PMC article.
618 results