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iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, Van Eyk JE, Tagliati M, Svendsen CN. Laperle AH, et al. Among authors: fulton an. Nat Med. 2020 Feb;26(2):289-299. doi: 10.1038/s41591-019-0739-1. Epub 2020 Jan 27. Nat Med. 2020. PMID: 31988461
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration.
Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN. Laperle AH, et al. Stem Cell Reports. 2023 Aug 8;18(8):1629-1642. doi: 10.1016/j.stemcr.2023.03.016. Epub 2023 Apr 20. Stem Cell Reports. 2023. PMID: 37084724 Free PMC article.