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iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
Nat Med. 2020 Feb;26(2):289-299. doi: 10.1038/s41591-019-0739-1. Epub 2020 Jan 27.
Nat Med. 2020.
PMID: 31988461
Young bone marrow transplantation preserves learning and memory in old mice.
Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN, Goodridge HS.
Das MM, et al. Among authors: roxas km.
Commun Biol. 2019 Feb 20;2:73. doi: 10.1038/s42003-019-0298-5. eCollection 2019.
Commun Biol. 2019.
PMID: 30820468
Free PMC article.
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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial.
Baloh RH, Johnson JP, Avalos P, Allred P, Svendsen S, Gowing G, Roxas K, Wu A, Donahue B, Osborne S, Lawless G, Shelley B, Wheeler K, Prina C, Fine D, Kendra-Romito T, Stokes H, Manoukian V, Muthukumaran A, Garcia L, Bañuelos MG, Godoy M, Bresee C, Yu H, Drazin D, Ross L, Naruse R, Babu H, Macklin EA, Vo A, Elsayegh A, Tourtellotte W, Maya M, Burford M, Diaz F, Patil CG, Lewis RA, Svendsen CN.
Baloh RH, et al.
Nat Med. 2022 Sep;28(9):1813-1822. doi: 10.1038/s41591-022-01956-3. Epub 2022 Sep 5.
Nat Med. 2022.
PMID: 36064599
Free PMC article.
Clinical Trial.
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Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration.
Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN.
Laperle AH, et al.
Stem Cell Reports. 2023 Aug 8;18(8):1629-1642. doi: 10.1016/j.stemcr.2023.03.016. Epub 2023 Apr 20.
Stem Cell Reports. 2023.
PMID: 37084724
Free PMC article.
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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain.
Chuapoco MR, Flytzanis NC, Goeden N, Christopher Octeau J, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich JK, Bishaw Y, Gore BB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V.
Chuapoco MR, et al. Among authors: roxas km.
Nat Nanotechnol. 2023 Oct;18(10):1241-1251. doi: 10.1038/s41565-023-01419-x. Epub 2023 Jul 10.
Nat Nanotechnol. 2023.
PMID: 37430038
Free PMC article.
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Intravenous functional gene transfer throughout the brain of non-human primates using AAV.
Chuapoco MR, Flytzanis NC, Goeden N, Octeau JC, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shaya TF, Vendemiatti J, Jang MJ, Mich J, Bishaw Y, Gore B, Omstead V, Taskin N, Weed N, Ting J, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V.
Chuapoco MR, et al. Among authors: roxas km.
Res Sq [Preprint]. 2023 Jan 13:rs.3.rs-1370972. doi: 10.21203/rs.3.rs-1370972/v1.
Res Sq. 2023.
PMID: 36789432
Free PMC article.
Updated.
Preprint.
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