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Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge.
Stapleton NM, Brinkhaus M, Armour KL, Bentlage AEH, de Taeye SW, Temming AR, Mok JY, Brasser G, Maas M, van Esch WJE, Clark MR, Williamson LM, van der Schoot CE, Vidarsson G. Stapleton NM, et al. Among authors: armour kl. Sci Rep. 2019 May 14;9(1):7363. doi: 10.1038/s41598-019-40731-2. Sci Rep. 2019. PMID: 31089170 Free PMC article.
Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers.
Ghevaert C, Herbert N, Hawkins L, Grehan N, Cookson P, Garner SF, Crisp-Hihn A, Lloyd-Evans P, Evans A, Balan K, Ouwehand WH, Armour KL, Clark MR, Williamson LM. Ghevaert C, et al. Among authors: armour kl. Blood. 2013 Jul 18;122(3):313-20. doi: 10.1182/blood-2013-02-481887. Epub 2013 May 8. Blood. 2013. PMID: 23656729 Free PMC article. Clinical Trial.
36 results