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Human and mouse essentiality screens as a resource for disease gene discovery.
Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D; Genomics England Research Consortium; International Mouse Phenotyping Consortium. Cacheiro P, et al. Among authors: konopka t. Nat Commun. 2020 Jan 31;11(1):655. doi: 10.1038/s41467-020-14284-2. Nat Commun. 2020. PMID: 32005800 Free PMC article.
Dimensional reduction of phenotypes from 53 000 mouse models reveals a diverse landscape of gene function.
Konopka T, Vestito L, Smedley D. Konopka T, et al. Bioinform Adv. 2021 Oct 11;1(1):vbab026. doi: 10.1093/bioadv/vbab026. eCollection 2021. Bioinform Adv. 2021. PMID: 34870209 Free PMC article.
The data underlying this article are available in Zenodo at https://doi.org/10.5281/zenodo.4916171. CONTACT: t.konopka@qmul.ac.uk. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online....
The data underlying this article are available in Zenodo at https://doi.org/10.5281/zenodo.4916171. CONTACT: t.konopka@qmul.ac …
A reversible gene trap collection empowers haploid genetics in human cells.
Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM. Bürckstümmer T, et al. Among authors: konopka t. Nat Methods. 2013 Oct;10(10):965-71. doi: 10.1038/nmeth.2609. Epub 2013 Aug 25. Nat Methods. 2013. PMID: 24161985 Free PMC article.
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Smida M, Fece de la Cruz F, Kerzendorfer C, Uras IZ, Mair B, Mazouzi A, Suchankova T, Konopka T, Katz AM, Paz K, Nagy-Bojarszky K, Muellner MK, Bago-Horvath Z, Haura EB, Loizou JI, Nijman SM. Smida M, et al. Among authors: konopka t. Nat Commun. 2016 Dec 6;7:13701. doi: 10.1038/ncomms13701. Nat Commun. 2016. PMID: 27922010 Free PMC article.
Piecewise polynomial representations of genomic tracks.
Tarabichi M, Detours V, Konopka T. Tarabichi M, et al. Among authors: konopka t. PLoS One. 2012;7(11):e48941. doi: 10.1371/journal.pone.0048941. Epub 2012 Nov 15. PLoS One. 2012. PMID: 23166601 Free PMC article.
118 results