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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.
Hansen JD, Correa M, Nagy MA, Alexander M, Plantevin V, Grant V, Whitefield B, Huang D, Kercher T, Harris R, Narla RK, Leisten J, Tang Y, Moghaddam M, Ebinger K, Piccotti J, Havens CG, Cathers B, Carmichael J, Daniel T, Vessey R, Hamann LG, Leftheris K, Mendy D, Baculi F, LeBrun LA, Khambatta G, Lopez-Girona A. Hansen JD, et al. Among authors: alexander m. J Med Chem. 2020 Jul 9;63(13):6648-6676. doi: 10.1021/acs.jmedchem.9b01928. Epub 2020 Mar 19. J Med Chem. 2020. PMID: 32130004
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
Hansen JD, Correa M, Alexander M, Nagy M, Huang D, Sapienza J, Lu G, LeBrun LA, Cathers BE, Zhang W, Tang Y, Ammirante M, Narla RK, Piccotti JR, Pourdehnad M, Lopez-Girona A. Hansen JD, et al. Among authors: alexander m. J Med Chem. 2021 Feb 25;64(4):1835-1843. doi: 10.1021/acs.jmedchem.0c01489. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33591756
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation.
Norris S, Ba X, Rhodes J, Huang D, Khambatta G, Buenviaje J, Nayak S, Meiring J, Reiss S, Xu S, Shi L, Whitefield B, Alexander M, Horn EJ, Correa M, Tehrani L, Hansen JD, Papa P, Mortensen DS. Norris S, et al. Among authors: alexander m. J Med Chem. 2023 Dec 14;66(23):16388-16409. doi: 10.1021/acs.jmedchem.3c01848. Epub 2023 Nov 22. J Med Chem. 2023. PMID: 37991844
A reinvestigation of the synthesis of Hantzsch's acid: comparison of derivatives of Hantzsch's acid with a product from the reaction of 2, 4,6-trichlorophenol and hypochlorite ion in methanol.
Heasley VL, Wadley BD, Alexander MD, Anderson JD, Anderson JH, Allen RT, Hernandez ML, Ismail ML, Sigmund GA, Shellhamer DF. Heasley VL, et al. Among authors: alexander md. J Org Chem. 2000 Nov 17;65(23):8111-3. doi: 10.1021/jo0010025. J Org Chem. 2000. PMID: 11073632 No abstract available.
Androgen receptor affinity of 5'-acyl furanosteroids.
Kumar V, Ackerman JH, Alexander MD, Bell MR, Christiansen RG, Dung JS, Jaeger EP, Herrmann JL Jr, Krolski ME, McKloskey P, et al. Kumar V, et al. Among authors: alexander md. J Med Chem. 1994 Nov 25;37(24):4227-36. doi: 10.1021/jm00050a019. J Med Chem. 1994. PMID: 7990121
Longitudinal changes in anthropometric, physiological, and physical qualities of international women's rugby league players.
Scantlebury S, Costello N, Owen C, Chantler S, Ramirez C, Zabaloy S, Collins N, Allen H, Phillips G, Alexander M, Barlow M, Williams E, Mackreth P, Barrow S, Parelkar P, Clarke A, Samuels B, Roe S, Blake C, Jones B. Scantlebury S, et al. Among authors: alexander m. PLoS One. 2024 May 14;19(5):e0298709. doi: 10.1371/journal.pone.0298709. eCollection 2024. PLoS One. 2024. PMID: 38743656 Free PMC article.
An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.
Chapple RH, Liu X, Natarajan S, Alexander MIM, Kim Y, Patel AG, LaFlamme CW, Pan M, Wright WC, Lee HM, Zhang Y, Lu M, Koo SC, Long C, Harper J, Savage C, Johnson MD, Confer T, Akers WJ, Dyer MA, Sheppard H, Easton J, Geeleher P. Chapple RH, et al. Among authors: alexander mim. bioRxiv [Preprint]. 2024 Apr 22:2023.04.13.536639. doi: 10.1101/2023.04.13.536639. bioRxiv. 2024. PMID: 38712039 Free PMC article. Preprint.
3,505 results