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Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.
Moreira-Teixeira L, Tabone O, Graham CM, Singhania A, Stavropoulos E, Redford PS, Chakravarty P, Priestnall SL, Suarez-Bonnet A, Herbert E, Mayer-Barber KD, Sher A, Fonseca KL, Sousa J, Cá B, Verma R, Haldar P, Saraiva M, O'Garra A. Moreira-Teixeira L, et al. Among authors: saraiva m. Nat Immunol. 2020 Apr;21(4):464-476. doi: 10.1038/s41590-020-0610-z. Epub 2020 Mar 16. Nat Immunol. 2020. PMID: 32205882 Free PMC article.
Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling.
Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M. Moreira-Teixeira L, et al. Among authors: saraiva m. J Immunol. 2016 Dec 15;197(12):4714-4726. doi: 10.4049/jimmunol.1600584. Epub 2016 Nov 14. J Immunol. 2016. PMID: 27849167 Free PMC article.
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
Moreira-Teixeira L, Stimpson PJ, Stavropoulos E, Hadebe S, Chakravarty P, Ioannou M, Aramburu IV, Herbert E, Priestnall SL, Suarez-Bonnet A, Sousa J, Fonseca KL, Wang Q, Vashakidze S, Rodríguez-Martínez P, Vilaplana C, Saraiva M, Papayannopoulos V, O'Garra A. Moreira-Teixeira L, et al. Among authors: saraiva m. Nat Commun. 2020 Nov 4;11(1):5566. doi: 10.1038/s41467-020-19412-6. Nat Commun. 2020. PMID: 33149141 Free PMC article.
TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production.
McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A. McNab FW, et al. Among authors: saraiva m. J Immunol. 2013 Aug 15;191(4):1732-43. doi: 10.4049/jimmunol.1300146. Epub 2013 Jul 10. J Immunol. 2013. PMID: 23842752 Free PMC article.
Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.
McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N, Saraiva M, O'Garra A. McNab FW, et al. Among authors: saraiva m. J Immunol. 2014 Oct 1;193(7):3600-12. doi: 10.4049/jimmunol.1401088. Epub 2014 Sep 3. J Immunol. 2014. PMID: 25187652 Free PMC article.
Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages.
Howes A, Taubert C, Blankley S, Spink N, Wu X, Graham CM, Zhao J, Saraiva M, Ricciardi-Castagnoli P, Bancroft GJ, O'Garra A. Howes A, et al. Among authors: saraiva m. J Immunol. 2016 Oct 1;197(7):2838-53. doi: 10.4049/jimmunol.1501923. Epub 2016 Aug 22. J Immunol. 2016. PMID: 27549173 Free PMC article.
Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns.
Silva ML, Cá B, Osório NS, Rodrigues PNS, Maceiras AR, Saraiva M. Silva ML, et al. Among authors: saraiva m. PLoS Pathog. 2022 May 26;18(5):e1010490. doi: 10.1371/journal.ppat.1010490. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35617217 Free PMC article. Review.
750 results