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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Schauer NJ, Liu X, Magin RS, Doherty LM, Chan WC, Ficarro SB, Hu W, Roberts RM, Iacob RE, Stolte B, Giacomelli AO, Perera S, McKay K, Boswell SA, Weisberg EL, Ray A, Chauhan D, Dhe-Paganon S, Anderson KC, Griffin JD, Li J, Hahn WC, Sorger PK, Engen JR, Stegmaier K, Marto JA, Buhrlage SJ. Schauer NJ, et al. Among authors: chan wc. Sci Rep. 2020 Mar 24;10(1):5324. doi: 10.1038/s41598-020-62076-x. Sci Rep. 2020. PMID: 32210275 Free PMC article.
Identification and validation of selective deubiquitinase inhibitors.
Varca AC, Casalena D, Chan WC, Hu B, Magin RS, Roberts RM, Liu X, Zhu H, Seo HS, Dhe-Paganon S, Marto JA, Auld D, Buhrlage SJ. Varca AC, et al. Among authors: chan wc. Cell Chem Biol. 2021 Dec 16;28(12):1758-1771.e13. doi: 10.1016/j.chembiol.2021.05.012. Epub 2021 Jun 14. Cell Chem Biol. 2021. PMID: 34129829 Free PMC article.
Chemoproteomic methods for covalent drug discovery.
Chan WC, Sharifzadeh S, Buhrlage SJ, Marto JA. Chan WC, et al. Chem Soc Rev. 2021 Aug 2;50(15):8361-8381. doi: 10.1039/d1cs00231g. Chem Soc Rev. 2021. PMID: 34143170 Free PMC article. Review.
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.
Yang J, Weisberg EL, Liu X, Magin RS, Chan WC, Hu B, Schauer NJ, Zhang S, Lamberto I, Doherty L, Meng C, Sattler M, Cabal-Hierro L, Winer E, Stone R, Marto JA, Griffin JD, Buhrlage SJ. Yang J, et al. Among authors: chan wc. Leukemia. 2022 Jan;36(1):210-220. doi: 10.1038/s41375-021-01336-9. Epub 2021 Jul 29. Leukemia. 2022. PMID: 34326465
On-Chip Preconcentration Microchip Capillary Electrophoresis Based CE-PRM-LIVE for High-Throughput Selectivity Profiling of Deubiquitinase Inhibitors.
Zhu H, Mellors JS, Chan WC, Thompson JW, Ficarro SB, Tavares I, Bratt AS, Decker J, Krause M, Kruppa G, Buhrlage SJ, Marto JA. Zhu H, et al. Among authors: chan wc. Anal Chem. 2022 Jul 12;94(27):9508-9513. doi: 10.1021/acs.analchem.2c01337. Epub 2022 Jun 21. Anal Chem. 2022. PMID: 35729701 Free PMC article.
Accelerating inhibitor discovery for deubiquitinating enzymes.
Chan WC, Liu X, Magin RS, Girardi NM, Ficarro SB, Hu W, Tarazona Guzman MI, Starnbach CA, Felix A, Adelmant G, Varca AC, Hu B, Bratt AS, DaSilva E, Schauer NJ, Jaen Maisonet I, Dolen EK, Ayala AX, Marto JA, Buhrlage SJ. Chan WC, et al. Nat Commun. 2023 Feb 8;14(1):686. doi: 10.1038/s41467-023-36246-0. Nat Commun. 2023. PMID: 36754960 Free PMC article.
1,119 results