Kastelein RA - Search Results

1

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab.

Hutchins B, Starling GC, McCoy MA, Herzyk D, Poulet FM, Dulos J, Liu L, Kang SP, Fayadat-Dilman L, Hsieh M, Andrews CL, Ayanoglu G, Cullen C, Malefyt RW, Kastelein RA, Saux SL, Lee J, Li S, Malashock D, Sadekova S, Soder G, van Eenennaam H, Willingham A, Yu Y, Streuli M, Carven GJ, van Elsas A. Hutchins B, et al. Among authors: kastelein ra. Mol Cancer Ther. 2020 Jun;19(6):1298-1307. doi: 10.1158/1535-7163.MCT-19-0774. Epub 2020 Mar 30. Mol Cancer Ther. 2020. PMID: 32229606

2

An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma.

Aspuria PJ, Vivona S, Bauer M, Semana M, Ratti N, McCauley S, Riener R, de Waal Malefyt R, Rokkam D, Emmerich J, Kastelein RA, Lupardus PJ, Oft M. Aspuria PJ, et al. Among authors: kastelein ra. Sci Transl Med. 2021 Dec 22;13(625):eabg7565. doi: 10.1126/scitranslmed.abg7565. Epub 2021 Dec 22. Sci Transl Med. 2021. PMID: 34936383

3

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, Liu YJ. Kadowaki N, et al. Among authors: kastelein ra. J Exp Med. 2001 Sep 17;194(6):863-9. doi: 10.1084/jem.194.6.863. J Exp Med. 2001. PMID: 11561001 Free PMC article.

4

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.

Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, Vives F, Moon C, Penaflor E, Turner S, Ayanoglu G, Chang C, Basham B, Mumm JB, Pierce RH, Yearley JH, McClanahan TK, Phillips JH, Cua DJ, Bowman EP, Kastelein RA, LaFace D. Chan IH, et al. Among authors: kastelein ra. Mucosal Immunol. 2014 Jul;7(4):842-56. doi: 10.1038/mi.2013.101. Epub 2013 Nov 27. Mucosal Immunol. 2014. PMID: 24280935 Free article.

5

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, Kleinschek MA, Owyang A, Mattson J, Blumenschein W, Murphy E, Sathe M, Cua DJ, Kastelein RA, Rennick D. Yen D, et al. Among authors: kastelein ra. J Clin Invest. 2006 May;116(5):1310-6. doi: 10.1172/JCI21404. J Clin Invest. 2006. PMID: 16670770 Free PMC article.

6

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation.

Kleinschek MA, Boniface K, Sadekova S, Grein J, Murphy EE, Turner SP, Raskin L, Desai B, Faubion WA, de Waal Malefyt R, Pierce RH, McClanahan T, Kastelein RA. Kleinschek MA, et al. Among authors: kastelein ra. J Exp Med. 2009 Mar 16;206(3):525-34. doi: 10.1084/jem.20081712. Epub 2009 Mar 9. J Exp Med. 2009. PMID: 19273624 Free PMC article.

7

Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins.

Koch-Nolte F, Petersen D, Balasubramanian S, Haag F, Kahlke D, Willer T, Kastelein R, Bazan F, Thiele HG. Koch-Nolte F, et al. J Biol Chem. 1996 Mar 29;271(13):7686-93. doi: 10.1074/jbc.271.13.7686. J Biol Chem. 1996. PMID: 8631807 Free article.

8

A family of human receptors structurally related to Drosophila Toll.

Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. Rock FL, et al. Among authors: kastelein ra. Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):588-93. doi: 10.1073/pnas.95.2.588. Proc Natl Acad Sci U S A. 1998. PMID: 9435236 Free PMC article.

9

A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.

Neighbors M, Xu X, Barrat FJ, Ruuls SR, Churakova T, Debets R, Bazan JF, Kastelein RA, Abrams JS, O'Garra A. Neighbors M, et al. Among authors: kastelein ra. J Exp Med. 2001 Aug 6;194(3):343-54. doi: 10.1084/jem.194.3.343. J Exp Med. 2001. PMID: 11489953 Free PMC article.

10

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.

Verreck FA, de Boer T, Langenberg DM, Hoeve MA, Kramer M, Vaisberg E, Kastelein R, Kolk A, de Waal-Malefyt R, Ottenhoff TH. Verreck FA, et al. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4560-5. doi: 10.1073/pnas.0400983101. Epub 2004 Mar 19. Proc Natl Acad Sci U S A. 2004. PMID: 15070757 Free PMC article.

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