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A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.
Ramasamy V, Arora U, Shukla R, Poddar A, Shanmugam RK, White LJ, Mattocks MM, Raut R, Perween A, Tyagi P, de Silva AM, Bhaumik SK, Kaja MK, Villinger F, Ahmed R, Johnston RE, Swaminathan S, Khanna N. Ramasamy V, et al. Among authors: shanmugam rk. PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006191. doi: 10.1371/journal.pntd.0006191. eCollection 2018 Jan. PLoS Negl Trop Dis. 2018. PMID: 29309412 Free PMC article.
Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models.
Shukla R, Beesetti H, Brown JA, Ahuja R, Ramasamy V, Shanmugam RK, Poddar A, Batra G, Krammer F, Lim JK, Kale S, Lal AA, Swaminathan S, Khanna N. Shukla R, et al. Among authors: shanmugam rk. EBioMedicine. 2020 Oct;60:102991. doi: 10.1016/j.ebiom.2020.102991. Epub 2020 Sep 16. EBioMedicine. 2020. PMID: 32949997 Free PMC article.
Cocculus hirsutus-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity.
Shukla R, Rajpoot RK, Poddar A, Ahuja R, Beesetti H, Shanmugam RK, Chaturvedi S, Nayyar K, Singh D, Singamaneni V, Gupta P, Gupta AP, Gairola S, Kumar P, Bedi YS, Jain T, Vashishta B, Patil R, Madan H, Madan S, Kalra R, Sood R, Vishwakarma RA, Reddy DS, Lal AA, Arora U, Khanna N. Shukla R, et al. Among authors: shanmugam rk. Front Microbiol. 2021 Nov 29;12:746110. doi: 10.3389/fmicb.2021.746110. eCollection 2021. Front Microbiol. 2021. PMID: 34912307 Free PMC article.
Association of HADHA with human RNA silencing machinery.
Kakumani PK, Shanmugam RK, Kaur I, Malhotra P, Mukherjee SK, Bhatnagar RK. Kakumani PK, et al. Among authors: shanmugam rk. Biochem Biophys Res Commun. 2015 Oct 23;466(3):481-5. doi: 10.1016/j.bbrc.2015.09.055. Epub 2015 Sep 11. Biochem Biophys Res Commun. 2015. PMID: 26367179