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Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.
Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. Hsiao F, et al. Among authors: lee gq, lee s. PLoS Pathog. 2020 Apr 30;16(4):e1008450. doi: 10.1371/journal.ppat.1008450. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32353080 Free PMC article.
HLA-C downregulation by HIV-1 adapts to host HLA genotype.
Bachtel ND, Umviligihozo G, Pickering S, Mota TM, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini CS, Cerqueira NB, O'Doherty UT, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R. Bachtel ND, et al. Among authors: lee gq. PLoS Pathog. 2018 Sep 4;14(9):e1007257. doi: 10.1371/journal.ppat.1007257. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30180214 Free PMC article.
HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy.
Stevenson EM, Ward AR, Truong R, Thomas AS, Huang SH, Dilling TR, Terry S, Bui JK, Mota TM, Danesh A, Lee GQ, Gramatica A, Khadka P, Alberto WDC, Gandhi RT, McMahon DK, Lalama CM, Bosch RJ, Macatangay B, Cyktor JC, Eron JJ, Mellors JW, Jones RB; AIDS Clinical Trials Group A5321 Team. Stevenson EM, et al. Among authors: lee gq. JCI Insight. 2021 Feb 8;6(3):e142640. doi: 10.1172/jci.insight.142640. JCI Insight. 2021. PMID: 33400687 Free PMC article.
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).
Kinloch NN, Ren Y, Conce Alberto WD, Dong W, Khadka P, Huang SH, Mota TM, Wilson A, Shahid A, Kirkby D, Harris M, Kovacs C, Benko E, Ostrowski MA, Del Rio Estrada PM, Wimpelberg A, Cannon C, Hardy WD, MacLaren L, Goldstein H, Brumme CJ, Lee GQ, Lynch RM, Brumme ZL, Jones RB. Kinloch NN, et al. Among authors: lee gq. Nat Commun. 2021 Jan 8;12(1):165. doi: 10.1038/s41467-020-20442-3. Nat Commun. 2021. PMID: 33420062 Free PMC article.
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells.
Stevenson EM, Terry S, Copertino D, Leyre L, Danesh A, Weiler J, Ward AR, Khadka P, McNeil E, Bernard K, Miller IG, Ellsworth GB, Johnston CD, Finkelsztein EJ, Zumbo P, Betel D, Dündar F, Duncan MC, Lapointe HR, Speckmaier S, Moran-Garcia N, Papa MP, Nicholes S, Stover CJ, Lynch RM, Caskey M, Gaebler C, Chun TW, Bosque A, Wilkin TJ, Lee GQ, Brumme ZL, Jones RB. Stevenson EM, et al. Among authors: lee gq. Nat Commun. 2022 Aug 19;13(1):4888. doi: 10.1038/s41467-022-32376-z. Nat Commun. 2022. PMID: 35985993 Free PMC article.
HIV reservoirs are dominated by genetically younger and clonally enriched proviruses.
Kinloch NN, Shahid A, Dong W, Kirkby D, Jones BR, Beelen CJ, MacMillan D, Lee GQ, Mota TM, Sudderuddin H, Barad E, Harris M, Brumme CJ, Jones RB, Brockman MA, Joy JB, Brumme ZL. Kinloch NN, et al. Among authors: lee gq. mBio. 2023 Nov 16;14(6):e0241723. doi: 10.1128/mbio.02417-23. Online ahead of print. mBio. 2023. PMID: 37971267 Free PMC article.
Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.
Lee GQ, Orlova-Fink N, Einkauf K, Chowdhury FZ, Sun X, Harrington S, Kuo HH, Hua S, Chen HR, Ouyang Z, Reddy K, Dong K, Ndung'u T, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M. Lee GQ, et al. J Clin Invest. 2017 Jun 30;127(7):2689-2696. doi: 10.1172/JCI93289. Epub 2017 Jun 19. J Clin Invest. 2017. PMID: 28628034 Free PMC article.
51 results