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The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.
Wettstein G, Luccarini JM, Poekes L, Faye P, Kupkowski F, Adarbes V, Defrêne E, Estivalet C, Gawronski X, Jantzen I, Philippot A, Tessier J, Tuyaa-Boustugue P, Oakley F, Mann DA, Leclercq I, Francque S, Konstantinova I, Broqua P, Junien JL. Wettstein G, et al. Hepatol Commun. 2017 Jun 19;1(6):524-537. doi: 10.1002/hep4.1057. eCollection 2017 Aug. Hepatol Commun. 2017. PMID: 29404476 Free PMC article.
Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease.
Boyer-Diaz Z, Aristu-Zabalza P, Andrés-Rozas M, Robert C, Ortega-Ribera M, Fernández-Iglesias A, Broqua P, Junien JL, Wettstein G, Bosch J, Gracia-Sancho J. Boyer-Diaz Z, et al. Among authors: wettstein g. J Hepatol. 2021 May;74(5):1188-1199. doi: 10.1016/j.jhep.2020.11.045. Epub 2020 Dec 2. J Hepatol. 2021. PMID: 33278455 Free article.
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.
Boubia B, Poupardin O, Barth M, Binet J, Peralba P, Mounier L, Jacquier E, Gauthier E, Lepais V, Chatar M, Ferry S, Thourigny A, Guillier F, Llacer J, Amaudrut J, Dodey P, Lacombe O, Masson P, Montalbetti C, Wettstein G, Luccarini JM, Legendre C, Junien JL, Broqua P. Boubia B, et al. Among authors: wettstein g. J Med Chem. 2018 Mar 22;61(6):2246-2265. doi: 10.1021/acs.jmedchem.7b01285. Epub 2018 Feb 27. J Med Chem. 2018. PMID: 29446942
Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3.
Thuringer D, Jego G, Wettstein G, Terrier O, Cronier L, Yousfi N, Hébrard S, Bouchot A, Hazoumé A, Joly AL, Gleave M, Rosa-Calatrava M, Solary E, Garrido C. Thuringer D, et al. Among authors: wettstein g. FASEB J. 2013 Oct;27(10):4169-83. doi: 10.1096/fj.12-226977. Epub 2013 Jun 26. FASEB J. 2013. PMID: 23804239
Heat shock proteins: cell protection through protein triage.
Lanneau D, Wettstein G, Bonniaud P, Garrido C. Lanneau D, et al. Among authors: wettstein g. ScientificWorldJournal. 2010 Aug 3;10:1543-52. doi: 10.1100/tsw.2010.152. ScientificWorldJournal. 2010. PMID: 20694452 Free PMC article. Review.
Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes.
Jego G, Lanneau D, De Thonel A, Berthenet K, Hazoumé A, Droin N, Hamman A, Girodon F, Bellaye PS, Wettstein G, Jacquel A, Duplomb L, Le Mouël A, Papanayotou C, Christians E, Bonniaud P, Lallemand-Mezger V, Solary E, Garrido C. Jego G, et al. Among authors: wettstein g. Leukemia. 2014 Aug;28(8):1676-86. doi: 10.1038/leu.2014.63. Epub 2014 Feb 7. Leukemia. 2014. PMID: 24504023
21 results