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Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice.
Guthrie LM, Soma S, Yuan S, Silva A, Zulkifli M, Snavely TC, Greene HF, Nunez E, Lynch B, De Ville C, Shanbhag V, Lopez FR, Acharya A, Petris MJ, Kim BE, Gohil VM, Sacchettini JC. Guthrie LM, et al. Among authors: snavely tc. Science. 2020 May 8;368(6491):620-625. doi: 10.1126/science.aaz8899. Science. 2020. PMID: 32381719 Free PMC article.
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC. Crespo RA, et al. Among authors: snavely tc. J Med Chem. 2019 May 9;62(9):4483-4499. doi: 10.1021/acs.jmedchem.9b00020. Epub 2019 Apr 19. J Med Chem. 2019. PMID: 31002508 Free PMC article.
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC. Aggarwal A, et al. Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29. Cell. 2017. PMID: 28669536 Free PMC article.