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Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770).
Delaunay JL, Bruneau A, Hoffmann B, Durand-Schneider AM, Barbu V, Jacquemin E, Maurice M, Housset C, Callebaut I, Aït-Slimane T. Delaunay JL, et al. Among authors: callebaut i. Hepatology. 2017 Feb;65(2):560-570. doi: 10.1002/hep.28929. Epub 2016 Dec 24. Hepatology. 2017. PMID: 28012258
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Froux L, Elbahnsi A, Boucherle B, Billet A, Baatallah N, Hoffmann B, Alliot J, Zelli R, Zeinyeh W, Haudecoeur R, Chevalier B, Fortuné A, Mirval S, Simard C, Lehn P, Mornon JP, Hinzpeter A, Becq F, Callebaut I, Décout JL. Froux L, et al. Among authors: callebaut i. Eur J Med Chem. 2020 Mar 15;190:112116. doi: 10.1016/j.ejmech.2020.112116. Epub 2020 Feb 9. Eur J Med Chem. 2020. PMID: 32078860
Structure-Based Understanding of ABCA3 Variants.
Onnée M, Fanen P, Callebaut I, de Becdelièvre A. Onnée M, et al. Among authors: callebaut i. Int J Mol Sci. 2021 Sep 24;22(19):10282. doi: 10.3390/ijms221910282. Int J Mol Sci. 2021. PMID: 34638622 Free PMC article.
New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.
Bitam S, Elbahnsi A, Creste G, Pranke I, Chevalier B, Berhal F, Hoffmann B, Servel N, Baatalah N, Tondelier D, Hatton A, Moquereau C, Faria Da Cunha M, Pastor A, Lepissier A, Hinzpeter A, Mornon JP, Prestat G, Edelman A, Callebaut I, Gravier-Pelletier C, Sermet-Gaudelus I. Bitam S, et al. Among authors: callebaut i. Sci Rep. 2021 Mar 25;11(1):6842. doi: 10.1038/s41598-021-83240-x. Sci Rep. 2021. PMID: 33767236 Free PMC article.
300 results