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The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells.
Sci Signal. 2020 Jun 2;13(634):eaaz1053. doi: 10.1126/scisignal.aaz1053.
Sci Signal. 2020.
PMID: 32487715
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.
Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, Ramirez-Carrozzi V, Sun Y, Grigg PW, Roose-Girma M, Jeet S, Barck KH, Pham A, Ota N, Ha C, Stinson J, Guillory J, Tam L, Modrusan Z, Emson C, McKenzie BS, Townsend MJ, Carano RAD, Warming S, Vucic D, DeVoss J, Lee WP, Lill JR, Zarrin AA.
Senger K, et al. Among authors: lau vwc.
Sci Signal. 2017 Apr 18;10(475):eaah4273. doi: 10.1126/scisignal.aah4273.
Sci Signal. 2017.
PMID: 28420753
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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.
Helsen CW, Hammill JA, Lau VWC, Mwawasi KA, Afsahi A, Bezverbnaya K, Newhook L, Hayes DL, Aarts C, Bojovic B, Denisova GF, Kwiecien JM, Brain I, Derocher H, Milne K, Nelson BH, Bramson JL.
Helsen CW, et al. Among authors: lau vwc.
Nat Commun. 2018 Aug 3;9(1):3049. doi: 10.1038/s41467-018-05395-y.
Nat Commun. 2018.
PMID: 30076299
Free PMC article.
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IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells.
Mazet JM, Mahale JN, Tong O, Watson RA, Lechuga-Vieco AV, Pirgova G, Lau VWC, Attar M, Koneva LA, Sansom SN, Fairfax BP, Gérard A.
Mazet JM, et al. Among authors: lau vwc.
Nat Commun. 2023 Jan 19;14(1):321. doi: 10.1038/s41467-023-35948-9.
Nat Commun. 2023.
PMID: 36658158
Free PMC article.
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Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency.
Yoo SM, Lau VWC, Aarts C, Bojovic B, Steinberg G, Hammill JA, Dvorkin-Gheva A, Ghosh R, Bramson JL.
Yoo SM, et al. Among authors: lau vwc.
Oncoimmunology. 2021 Nov 9;10(1):1995168. doi: 10.1080/2162402X.2021.1995168. eCollection 2021.
Oncoimmunology. 2021.
PMID: 34777917
Free PMC article.
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A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity.
Hammill JA, Kwiecien JM, Dvorkin-Gheva A, Lau VWC, Baker C, Wu Y, Bezverbnaya K, Aarts C, Heslen CW, Denisova GF, Derocher H, Milne K, Nelson BH, Bramson JL.
Hammill JA, et al. Among authors: lau vwc.
Mol Ther Oncolytics. 2020 Apr 14;17:278-292. doi: 10.1016/j.omto.2020.04.001. eCollection 2020 Jun 26.
Mol Ther Oncolytics. 2020.
PMID: 32368616
Free PMC article.
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Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells.
Prota G, Gileadi U, Rei M, Lechuga-Vieco AV, Chen JL, Galiani S, Bedard M, Lau VWC, Fanchi LF, Artibani M, Hu Z, Gordon S, Rehwinkel J, Enríquez JA, Ahmed AA, Schumacher TN, Cerundolo V.
Prota G, et al. Among authors: lau vwc.
Cancer Immunol Res. 2020 May;8(5):685-697. doi: 10.1158/2326-6066.CIR-19-0467. Epub 2020 Mar 23.
Cancer Immunol Res. 2020.
PMID: 32205315
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Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents.
Lelic A, Verschoor CP, Lau VW, Parsons R, Evelegh C, Bowdish DM, Bramson JL, Loeb MB.
Lelic A, et al.
J Infect Dis. 2016 Dec 15;214(12):1905-1910. doi: 10.1093/infdis/jiw462. Epub 2016 Oct 5.
J Infect Dis. 2016.
PMID: 27707807
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