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The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells.
Corzo CA, Varfolomeev E, Setiadi AF, Francis R, Klabunde S, Senger K, Sujatha-Bhaskar S, Drobnick J, Do S, Suto E, Huang Z, Eastham-Anderson J, Katewa A, Pang J, Domeyer M, Dela Cruz C, Paler-Martinez A, Lau VWC, Hadadianpour A, Ramirez-Carrozi V, Sun Y, Bao K, Xu D, Hunley E, Brightbill HD, Warming S, Roose-Girma M, Wong A, Tam L, Emson CL, Crawford JJ, Young WB, Pappu R, McKenzie BS, Asghari V, Vucic D, Hackney JA, Austin CD, Lee WP, Lekkerkerker A, Ghilardi N, Bryan MC, Kiefer JR, Townsend MJ, Zarrin AA. Corzo CA, et al. Among authors: zarrin aa. Sci Signal. 2020 Jun 2;13(634):eaaz1053. doi: 10.1126/scisignal.aaz1053. Sci Signal. 2020. PMID: 32487715
Kinase inhibition in autoimmunity and inflammation.
Zarrin AA, Bao K, Lupardus P, Vucic D. Zarrin AA, et al. Nat Rev Drug Discov. 2021 Jan;20(1):39-63. doi: 10.1038/s41573-020-0082-8. Epub 2020 Oct 19. Nat Rev Drug Discov. 2021. PMID: 33077936 Free PMC article. Review.
Treg specialization and functions beyond immune suppression.
Astarita JL, Dominguez CX, Tan C, Guillen J, Pauli ML, Labastida R, Valle J, Kleinschek M, Lyons J, Zarrin AA. Astarita JL, et al. Among authors: zarrin aa. Clin Exp Immunol. 2023 Mar 16;211(2):176-183. doi: 10.1093/cei/uxac123. Clin Exp Immunol. 2023. PMID: 36571811 Free PMC article. Review.
Prognostic accuracy of emergency surgery score: a systematic review.
Toloui A, Kiah M, Zarrin AA, Azizi Y, Yousefifard M. Toloui A, et al. Among authors: zarrin aa. Eur J Trauma Emerg Surg. 2023 Dec 18. doi: 10.1007/s00068-023-02396-5. Online ahead of print. Eur J Trauma Emerg Surg. 2023. PMID: 38108839 Review.
Tpl2 kinase regulates inflammation but not tumorigenesis in mice.
Wu KC, Cain G, Corpuz J, Xu D, Ljumanovic N, Zarrin AA. Wu KC, et al. Among authors: zarrin aa. Toxicol Appl Pharmacol. 2021 May 1;418:115494. doi: 10.1016/j.taap.2021.115494. Epub 2021 Mar 13. Toxicol Appl Pharmacol. 2021. PMID: 33722668
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
Rajapaksa NS, Gobbi A, Drobnick J, Do S, Kolesnikov A, Liang J, Chen Y, Sujatha-Bhaskar S, Huang Z, Brightbill H, Francis R, Yu C, Choo EF, DeMent K, Ran Y, An L, Emson C, Maher J, Wai J, McKenzie BS, Lupardus PJ, Zarrin AA, Kiefer JR, Bryan MC. Rajapaksa NS, et al. Among authors: zarrin aa. ACS Med Chem Lett. 2019 Nov 11;11(3):327-333. doi: 10.1021/acsmedchemlett.9b00380. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184965 Free PMC article.
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.
Lin W, Xu D, Austin CD, Caplazi P, Senger K, Sun Y, Jeet S, Young J, Delarosa D, Suto E, Huang Z, Zhang J, Yan D, Corzo C, Barck K, Rajan S, Looney C, Gandham V, Lesch J, Liang WC, Mai E, Ngu H, Ratti N, Chen Y, Misner D, Lin T, Danilenko D, Katavolos P, Doudemont E, Uppal H, Eastham J, Mak J, de Almeida PE, Bao K, Hadadianpour A, Keir M, Carano RAD, Diehl L, Xu M, Wu Y, Weimer RM, DeVoss J, Lee WP, Balazs M, Walsh K, Alatsis KR, Martin F, Zarrin AA. Lin W, et al. Among authors: zarrin aa. Front Immunol. 2019 Sep 4;10:2019. doi: 10.3389/fimmu.2019.02019. eCollection 2019. Front Immunol. 2019. PMID: 31552020 Free PMC article.
44 results