Graham RL - Search Results

1

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, Graham RL, Perry JK, Du Pont V, Pitts J, Ma B, Babusis D, Murakami E, Feng JY, Bilello JP, Porter DP, Cihlar T, Baric RS, Denison MR, Sheahan TP. Pruijssers AJ, et al. Among authors: graham rl. bioRxiv [Preprint]. 2020 Apr 27:2020.04.27.064279. doi: 10.1101/2020.04.27.064279. bioRxiv. 2020. PMID: 32511392 Free PMC article. Updated. Preprint.

2

Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication.

Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Denison MR, et al. Among authors: graham rl. J Virol. 2004 Jun;78(11):5957-65. doi: 10.1128/JVI.78.11.5957-5965.2004. J Virol. 2004. PMID: 15140993 Free PMC article.

3

Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice.

Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Sperry SM, et al. Among authors: graham rl. J Virol. 2005 Mar;79(6):3391-400. doi: 10.1128/JVI.79.6.3391-3400.2005. J Virol. 2005. PMID: 15731233 Free PMC article.

4

The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication.

Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. Graham RL, et al. J Virol. 2005 Nov;79(21):13399-411. doi: 10.1128/JVI.79.21.13399-13411.2005. J Virol. 2005. PMID: 16227261 Free PMC article.

5

Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.

Graham RL, Denison MR. Graham RL, et al. J Virol. 2006 Dec;80(23):11610-20. doi: 10.1128/JVI.01428-06. Epub 2006 Sep 13. J Virol. 2006. PMID: 16971428 Free PMC article.

6

The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication.

Graham RL, Sims AC, Baric RS, Denison MR. Graham RL, et al. Adv Exp Med Biol. 2006;581:67-72. doi: 10.1007/978-0-387-33012-9_10. Adv Exp Med Biol. 2006. PMID: 17037506 Free PMC article.

7

MHV-A59 ORF1a replicase protein nsp7-nsp10 processing in replication.

Deming DJ, Graham RL, Denison MR, Baric RS. Deming DJ, et al. Among authors: graham rl. Adv Exp Med Biol. 2006;581:101-4. doi: 10.1007/978-0-387-33012-9_17. Adv Exp Med Biol. 2006. PMID: 17037513 Free PMC article. No abstract available.

8

Murine hepatitis virus replicase protein nsp10 is a critical regulator of viral RNA synthesis.

Donaldson EF, Sims AC, Graham RL, Denison MR, Baric RS. Donaldson EF, et al. Among authors: graham rl. J Virol. 2007 Jun;81(12):6356-68. doi: 10.1128/JVI.02805-06. Epub 2007 Mar 28. J Virol. 2007. PMID: 17392363 Free PMC article.

9

SARS coronavirus replicase proteins in pathogenesis.

Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR. Graham RL, et al. Virus Res. 2008 Apr;133(1):88-100. doi: 10.1016/j.virusres.2007.02.017. Epub 2007 Mar 29. Virus Res. 2008. PMID: 17397959 Free PMC article.

10

Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processing.

Donaldson EF, Graham RL, Sims AC, Denison MR, Baric RS. Donaldson EF, et al. Among authors: graham rl. J Virol. 2007 Jul;81(13):7086-98. doi: 10.1128/JVI.00049-07. Epub 2007 Apr 11. J Virol. 2007. PMID: 17428870 Free PMC article.

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