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Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.
Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok LSC, Loudon KW, Banham GD, Mathews RJ, Cader Z, Fitzpatrick S, Bashant KR, Kaplan MJ, Kaser A, Johnson RS, Murphy MP, Siegel RM, Clatworthy MR. Jing C, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15160-15171. doi: 10.1073/pnas.2000943117. Epub 2020 Jun 15. Proc Natl Acad Sci U S A. 2020. PMID: 32541026 Free PMC article.
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.
Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP. Prime TA, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15. Proc Natl Acad Sci U S A. 2009. PMID: 19528654 Free PMC article.
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. Kazak L, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19. Proc Natl Acad Sci U S A. 2017. PMID: 28630339 Free PMC article.
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP. Booty LM, et al. Among authors: murphy mp. Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31. Cell Chem Biol. 2019. PMID: 30713096 Free PMC article.
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM. Jedrychowski MP, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2020 May 19;117(20):10789-10796. doi: 10.1073/pnas.2001387117. Epub 2020 May 1. Proc Natl Acad Sci U S A. 2020. PMID: 32358195 Free PMC article.
Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models.
Hamed M, Logan A, Gruszczyk AV, Beach TE, James AM, Dare AJ, Barlow A, Martin J, Georgakopoulos N, Gane AM, Crick K, Fouto D, Fear C, Thiru S, Dolezalova N, Ferdinand JR, Clatworthy MR, Hosgood SA, Nicholson ML, Murphy MP, Saeb-Parsy K. Hamed M, et al. Among authors: murphy mp. Br J Surg. 2021 Sep 27;108(9):1072-1081. doi: 10.1093/bjs/znab108. Br J Surg. 2021. PMID: 33963377
Delivery of bioactive molecules to mitochondria in vivo.
Smith RA, Porteous CM, Gane AM, Murphy MP. Smith RA, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5407-12. doi: 10.1073/pnas.0931245100. Epub 2003 Apr 15. Proc Natl Acad Sci U S A. 2003. PMID: 12697897 Free PMC article.
794 results