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Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism.
Puca AA, Carrizzo A, Spinelli C, Damato A, Ambrosio M, Villa F, Ferrario A, Maciag A, Fornai F, Lenzi P, Valenti V, di Nonno F, Accarino G, Madonna M, Forte M, Calì G, Baragetti A, Norata GD, Catapano AL, Cattaneo M, Izzo R, Trimarco V, Montella F, Versaci F, Auricchio A, Frati G, Sciarretta S, Madeddu P, Ciaglia E, Vecchione C. Puca AA, et al. Among authors: madeddu p. Eur Heart J. 2020 Jul 7;41(26):2487-2497. doi: 10.1093/eurheartj/ehz459. Eur Heart J. 2020. PMID: 31289820 Free PMC article.
Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38+ macrophages and NAD+ decline.
Ciaglia E, Lopardo V, Montella F, Carrizzo A, Di Pietro P, Malavolta M, Giacconi R, Orlando F, Cattaneo M, Madeddu P, Vecchione C, Puca AA. Ciaglia E, et al. Among authors: madeddu p. Cell Death Dis. 2022 Jan 27;13(1):86. doi: 10.1038/s41419-022-04535-z. Cell Death Dis. 2022. PMID: 35087020 Free PMC article.
Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.
Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Calì G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA. Villa F, et al. Among authors: madeddu p. Circ Res. 2015 Jul 31;117(4):333-45. doi: 10.1161/CIRCRESAHA.117.305875. Epub 2015 Jun 1. Circ Res. 2015. PMID: 26034043 Free PMC article.
LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
Malavolta M, Dato S, Villa F, Rango F, Iannone F, Ferrario A, Maciag A, Ciaglia E, D'amato A, Carrizzo A, Basso A, Orlando F, Provinciali M, Madeddu P, Passarino G, Vecchione C, Rose G, Puca AA. Malavolta M, et al. Among authors: madeddu p. Aging (Albany NY). 2019 Aug 28;11(16):6555-6568. doi: 10.18632/aging.102209. Epub 2019 Aug 28. Aging (Albany NY). 2019. PMID: 31461407 Free PMC article.
Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway.
Dang Z, Avolio E, Thomas AC, Faulkner A, Beltrami AP, Cervellin C, Carrizzo A, Maciag A, Gu Y, Ciaglia E, Finato N, Damato A, Spinetti G, Alenzi A, Paisey SJ, Vecchione C, Puca AA, Madeddu P. Dang Z, et al. Among authors: madeddu p. Eur J Heart Fail. 2020 Sep;22(9):1568-1581. doi: 10.1002/ejhf.1840. Epub 2020 May 8. Eur J Heart Fail. 2020. PMID: 32384208 Free PMC article.
Corrigendum to: "The genetics of exceptional longevity identifies new druggable targets for vascular protection and repair" [Pharmacol. Res. 114 (December) (2016) 169-174. doi: 10.1016/j.phrs.2016.10.028. Epub 2016 Nov 3].
Puca AA, Spinetti G, Vono R, Vecchione C, Madeddu P. Puca AA, et al. Among authors: madeddu p. Pharmacol Res. 2017 May;119:477. doi: 10.1016/j.phrs.2017.01.029. Epub 2017 Feb 11. Pharmacol Res. 2017. PMID: 28196703 No abstract available.
Correction for: LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
Malavolta M, Dato S, Villa F, De Rango F, Iannone F, Ferrario A, Maciag A, Ciaglia E, D'amato A, Carrizzo A, Basso A, Orlando F, Provinciali M, Madeddu P, Passarino G, Vecchione C, Rose G, Puca AA. Malavolta M, et al. Among authors: madeddu p. Aging (Albany NY). 2019 Oct 25;11(20):9220. doi: 10.18632/aging.102398. Epub 2019 Oct 25. Aging (Albany NY). 2019. PMID: 31682235 Free PMC article. No abstract available.
339 results