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Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, Maystadt I, Füchtbauer A, Füchtbauer EM, Jablonka S, Blum R, Üçeyler N, Petri S, Kaltschmidt B, Jahn R, Kaltschmidt C, Sendtner M. Lüningschrör P, et al. Nat Commun. 2017 Oct 30;8(1):678. doi: 10.1038/s41467-017-00689-z. Nat Commun. 2017. PMID: 29084947 Free PMC article.
Autophagy in the presynaptic compartment.
Lüningschrör P, Sendtner M. Lüningschrör P, et al. Curr Opin Neurobiol. 2018 Aug;51:80-85. doi: 10.1016/j.conb.2018.02.023. Epub 2018 Mar 14. Curr Opin Neurobiol. 2018. PMID: 29549710 Review.
Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice.
Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. Brenner D, et al. Among authors: luningschror p. J Exp Med. 2019 Feb 4;216(2):267-278. doi: 10.1084/jem.20180729. Epub 2019 Jan 11. J Exp Med. 2019. PMID: 30635357 Free PMC article.
The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M. Lüningschrör P, et al. Cell Rep. 2020 Mar 10;30(10):3506-3519.e6. doi: 10.1016/j.celrep.2020.02.060. Cell Rep. 2020. PMID: 32160553 Free article.
Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves.
Lüningschrör P, Slotta C, Heimann P, Briese M, Weikert UM, Massih B, Appenzeller S, Sendtner M, Kaltschmidt C, Kaltschmidt B. Lüningschrör P, et al. Front Cell Neurosci. 2020 Jul 7;14:185. doi: 10.3389/fncel.2020.00185. eCollection 2020. Front Cell Neurosci. 2020. PMID: 32733205 Free PMC article.
24 results