Thompson CB - Search Results

1

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.

Vardhana SA, Hwee MA, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink MRM, Cross JR, Thompson CB. Vardhana SA, et al. Among authors: thompson cb. Nat Immunol. 2020 Sep;21(9):1022-1033. doi: 10.1038/s41590-020-0725-2. Epub 2020 Jul 13. Nat Immunol. 2020. PMID: 32661364 Free PMC article.

2

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB. Rathmell JC, et al. Among authors: thompson cb. Nat Immunol. 2002 Oct;3(10):932-9. doi: 10.1038/ni834. Epub 2002 Sep 3. Nat Immunol. 2002. PMID: 12244308

3

Fuel feeds function: energy metabolism and the T-cell response.

Fox CJ, Hammerman PS, Thompson CB. Fox CJ, et al. Among authors: thompson cb. Nat Rev Immunol. 2005 Nov;5(11):844-52. doi: 10.1038/nri1710. Nat Rev Immunol. 2005. PMID: 16239903 Review.

4

ATP-citrate lyase links cellular metabolism to histone acetylation.

Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. Wellen KE, et al. Among authors: thompson cb. Science. 2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097. Science. 2009. PMID: 19461003 Free PMC article.

5

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production.

Ward PS, Cross JR, Lu C, Weigert O, Abel-Wahab O, Levine RL, Weinstock DM, Sharp KA, Thompson CB. Ward PS, et al. Among authors: thompson cb. Oncogene. 2012 May 10;31(19):2491-8. doi: 10.1038/onc.2011.416. Epub 2011 Sep 26. Oncogene. 2012. PMID: 21996744 Free PMC article.

6

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.

Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Wise DR, et al. Among authors: thompson cb. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6. doi: 10.1073/pnas.1117773108. Epub 2011 Nov 21. Proc Natl Acad Sci U S A. 2011. PMID: 22106302 Free PMC article.

7

Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.

Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Andreu-Agullo C, et al. Among authors: thompson cb. Nature. 2011 Dec 25;481(7380):195-8. doi: 10.1038/nature10712. Nature. 2011. PMID: 22198669 Free PMC article.

8

IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. Lu C, et al. Among authors: thompson cb. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860. Nature. 2012. PMID: 22343901 Free PMC article.

9

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB. Ward PS, et al. Among authors: thompson cb. J Biol Chem. 2013 Feb 8;288(6):3804-15. doi: 10.1074/jbc.M112.435495. Epub 2012 Dec 21. J Biol Chem. 2013. PMID: 23264629 Free PMC article.

10

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.

Chen C, Liu Y, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Chen C, et al. Genes Dev. 2013 Sep 15;27(18):1974-85. doi: 10.1101/gad.226613.113. Genes Dev. 2013. PMID: 24065765 Free PMC article.

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